| Objective:To study the aligning particles in chronic kidney Jieyu unpredictable mild stress depression model the behavior of rats and hypothalamic monoamine neurotransmitters (NE ,5-HT) levels and to explore aligning kidney Relieving effect of particle mechanism of the treatment of depression.Method: 1. The mice were randomly divided into 5 groups: normal group, fluoxetine hydrochloride capsule group, spherical particles kidney Jieyu low, medium and high dose group; The rats were randomly divided into 6 groups: normal group, depression model group, fluoxetine hydrochloride capsule group, spherical particles kidney Jieyu low, medium and high dose group. 2. To the mouse forced swimming test; to rat isolated custody and chronic unpredictable mild stimulation of the composite modeling approach, the establishment of stress in a rat model of depression. 3. Measurement of the immobility time of mice swimming; measuring the weight of the rats, open field test scores, sugar consumption and hypothalamic monoamine neurotransmitters (NE ,5-HT) content.Results: Spherical particles can be reduced kidney Jieyu swimming immobility time in mice; spherical particles can be adjusted Jieyu kidney weight of rats, open box test scores, sugar consumption; improve hypothalamic neurotransmitters (NE, 5 -HT) content.Conclusion: 1. Using isolated custody and chronic unpredictable mild stimulation of the composite modeling method can be successfully prepared animal models of depression and stress. 2. Determination of the indicators in this study showed: Spherical particles can be reduced kidney Jieyu swimming immobility time in mice, the role of considerable strength and fluoxetine group; spherical particles can be adjusted model kidney Jieyu rat body weight, behavior, improve the neurotransmitters. 3. Jieyu Spherical particles have the traffic heart, kidney, kidney, active Phlegm, soothe the nerves brain, antidepressant effect, it is worth further research and development. |
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