Type 2 Diabetic Patients With Metabolic Disorder In The Chinese Medicine Syndrome Research

This paper consists of two parts which include two summaries of document anda clinical study.There are two summaries of document. The first one summary the knowledge of Chinese medicine on type 2 diabetes mellitus complicating dyslipidemia, including the name of the disease, pathogenic, pathogenesis, pattern of syndrome, differentiation and treatment of common syndromes and animal experiment. The second one summary modern medicine studies on type 2 diabetes mellitus complicating dyslipidemia including its epidemic, pathogenic-factor, pathogen-esis, diagnosis standard and treatment.This is clinical studyObjective:Compare the differences of the syndrome between type 2 diabetes mellitus with dyslipidemia and the ones with non-dyslipidemia, reveal the symptomatology characters of the type 2 diabetes mellitus with dyslipidemia. settle a foundation standardization of syndrome differentiation of the disease, observe if there is difference in BMI,HbA1c,FPG,ApoA1,ApoB,age and course between patients with hyperlipoidemia and the ones with non-dyslipidemia.Methods:155 cases of patients with type 2 diabetes mellitus divided into two groups according to dyslipidemia. The syndrome involves Yin deficiency syndrome, Yan deficiency syndrome, Qi deficiency syndrome, Blood deficiency syndrome, qi stagnation syndrome, blood stasis syndrome, phlegm-dampness syndrome, Heat twisting syndrome, Heat accumulation syndrome and damp-heat syndrome. Measure the TC,TG,LDL-C,HDL-C,BMI,FPG,HbAlc of the patients and record their age, gender and course of disease. Then use SPSS13.0 to analyze the data.Results:Firstly,the results show that there is no significant difference between the groups of dyslipidemia and non-dyslipidemia on the age, gender and course of disease (P>0.05). Secondly, there is significant difference between the groups of dyslipidemia and non-dyslipidemia on phlegm-dampness syndrome and blood stasis syndrome(P<0.05). Thirdly, there is significant difference between the groups of dyslipidemia and non-dyslipidemia on the complications of diabetic nephropathy and diabetic retinopathy(P<0.05). Fourth, The study also shows the result that the significantly positive relationship between the integrals of blood stasis syndrome and TG level (P<0.05). There is significantly negative relationship among the integrals of blood stasis syndrome, HDL-C and apoAl levels (P<0.05). There is significantly positive relationship between the integrals of phlegm-dampness syndrome and TG level (P <0.05). There is signific-icantly negative relationship between the integrals of phlegm-dampness syndrome and HDL-C level (P<0.05). There is the significantly positive relationship among the integrals of Yan deficiency syndrome, the HDL-C and apoA1 levels (P<0.05). There is no significant relationship among the integrals of Yin deficiency syndrome, Qi deficiency syndrome, Blood deficiency syndrome, qi stagnation syndrome, Heat twisting syndrome, Heat accumulation syndrome, damp-heat syndrome and the different blood lipid indexes (P>0.05). The last, there is significant difference on the systolic blood pressure, diastolic blood pressure, BMI and apoB level (P<0.05).Conclusion:Phlegm-dampness syndrome, blood stasis syndrome, Yin deficiency syndrome, Qi deficiency syndrome are the main syndromes of the type 2 diabetes mellitus with dyslipidemia. The phlegm-dampness syndrome and blood stasis syndrome are the most obvious. Phlegm and blood stasis is the key pathogenesis of type 2 diabetes mellitus with dyslipidemia.The prevalence of diabetic nephropathy and diabetic retinopathy is significantly higher than control group(P<0.05). There is positive relationship among phlegm-dampness syndrome, blood stasis syndrome and Hypertriglyceridemia. There is negative relationship among phlegm-dampness syndrome, blood stasis syndrome and Low high-density lipoprotein cholesterol. There is negative relationship between blood stasis syndrome and apoAl level. There is positive relationship between Yan deficiency and HDL-C apoB level. The levels of systolic blood pressure, diastolic blood pressure, BMI and apoB are obviously higher than control group (P<0.05).