The Crowd Brucellosis In Pastoral Areas Of Risk Factors In The Inner Mongolia Autonomous Region Abagaqi Research

BackgroundBrucellosis recognized as an allergic and zoonotic infection,is caused by bacteria of the genus Brucella.Human brucellosis remains the commonest zoonotic disease worldwide with more than 500 000 new cases annually,Brucellosis is responsible for enormous economical losses as well as considerable human morbidity in endemic countries.In the past two decades,the case of brucellosis has been raised obviously,especially in some countries of Aisa and the Near East region bruceUosis had been well controlled in China,in 1992,human brucellosis incidence was 0.01/100,000.In the past decades,human brucellosis incidence has been increased from 0.25/100,000 in the year of 1996 to 2.09/100,000 in the year of 2008.Inner Mongolia Autonomous Region is one of the biggest grazing district in china,the incidence of Inner Mongolia Autonomous Region play an important role in brucellosis epidemiology of china.In 2006,the incidence of brucellosis in Inner Mongolia Autonomous Region was 35.24/100,000,and the number of new case was above 1/3 to the total case of China.ObjectsThe aims of the study were to investigate the seroprevalence of Brucella antibodies in residenter of Abaga County,and to elucidate possible risk factors associated with brucellosis,provide evidences for prevention and control brucellosis related policy in Inner Mongolia Autonomous Region.MethodsAbaga County of Inner Mongolia Autonomous Region was selected for this study. A cross-sectional study,with a two-stage sampling design according 'countyâ†'townshipâ†'village' was carried out,the villages were selected by random sampling,and all residenter in the selected village were surveyed with a questionnaire.The sera were collected while informant present the clinical symptom of brucellosis,the sera of residenter were collected who live in the same village match sex and age and no the clinical symptom of brucellosis.Initially,all collected sera were tested using Rose Bengal Plate Test "RBPT".Samples with positive and inconclusive results were further tested using Serum Agglutination Test "SAT".The risk factors associated with brucellosis analyzed by univariable analysis and multivariable logistic analysis.Results1.In Abaga County,the univariable analysis revealed the variables associated with sociological,sex,age,occupation,statistics significance with P＜0.05.2.In Abaga County,the univariable analysis,there were thirteen factor(feeding livestock(OR=3.02,95%CI=1.94～4.71 ),grazing(OR=2.25,95%CI=1.59～3.18),sheep-shearing(OR=2.79,95%CI=1.93～4.05),comb wool(OR=3.02, 95%CI=1.85～4.30),immunizing livestock(OR=2.39,95%CI=1.71～3.35), peeling(OR=1.95,95%CI=1.43～2.64),hold lamb(OR=1.82,95%CI=1.15～2.86),slaughter sick livestock(OR=1.64,95%CI=1.10～2.70),care sick livestock(OR=1.67,95%CI=1.10～2.65),deal with abortion(OR=2.09,95%CI =1.50～2.90),deal with manure(OR=2.26,95%CI=1.56～3.28),milking (OR=1.89,95%CI=1.15～3.08) shows significant differences between sera-positive groups and controls groups(P＜0.05),indicates these factor were potential risk factor to human brucellosis.3.There were 96.73%persons among informants heard brucellosis,above 80% persons correctly answered questionnaire questions which relate to safeguard resist to Brucella infection,and only less half of the informants could correctly answered questionnaire questions which relate to the route of brucellosis transmit from livestock to human.4.The variables revealed with univariable analysis(P＜0.05) were further analyzed using the multivariable logistic regression model.It indicates sex,abortion number of goat,deal with abortion,milking and comb wool were potential risk factors to human brucellosis in Abaga County.Conclusions1.The infected livestock by Brucella were source of human brucellosis.Sheep and goat infected brucella were the important factor influence Abaga County human brucellosis.Behavior without protected when touching infected livestock was potential risk factor of human brucellosis.2.The inhabitants of Abaga County didn't regard brucellosis serious,and without effective protection when deal with the questionable livestock. 3.Vaccination is protect factor for livestock abortion,on the other hand,it probably became a risk factor because of error vaccination performance,or because of possible changed virulence of Brucella vaccine.