| Purpose:Sanjin Lidan Paishi Decoction is the instructor in the basic theory of traditional Chinese medicine under the guidance of multi-year summary of the treatment group's experience, clinical experience is to, through dozens of confirmed cases of clinical observation Paishi good, and choleretic effect. Cholelithiasis is a starting point for the study of the choleretic side to change the role of bile composition and mechanism of the experimental animal study to examine the mechanisms to the prevention of cholelithiasis, with a view to the adoption of experimental studies, the enrichment and development of prevention and treatment of gallstone disease theoretical knowledge and clinical treatment for the experiment to provide a solid basis, and the development of an effective prescription treatment of cholelithiasis, aimed at lifting the majority of pain in patients with cholelithiasis. By observing the Sanjin Lidan Paishi Decoction bile of normal rats and the bile secretion of total bilirubin, free bilirubin and bile acid content, research and prevention of its choleretic effect and its mechanism of cholelithiasis, Clinical applications for the future solid theoretical basis.Material and method:Rats were randomly divided into normal control group, positive control group, three gold cholagogic Paishi Decoction group, through the direct administration of the duodenum, common bile duct cannulation bile collection; were collected 1 hour before delivery and to 1,2,3 hours after drug bile, measuring the time of bile secretion in rats and determination of bile total bilirubin, free bilirubin and bile acid content. Comparing the periods before and after administration of bile secretion in rats, total bilirubin content of bile, free bilirubin and bile acid content of change; comparison group of rats after administration of the time the volume of bile secretion, bile TBil Content, free bilirubin content of bile acid content and the rate of change. Results:Sanjin Lidan Paishi Decoction administration can be a significant increase in 1,2 hours after the bile flow in rats, the increase in 1,2 hours after administration the effect of significantly (P<0.01) and higher than the positive control group (P<0.01) ; after administration of bile secretion of total bilirubin had no significant change (P>0.05); can significantly reduce the bile after administration of 1,2-hour ratio of free bilirubin (P<0.01), to reduce the rate of its delivery after 1 (P<0.01) and 2 (P<0.05) an hour and the effect of significantly higher than the positive control group (P<0.05); could be increased significantly after administration of 1,2 (P<0.01) and 3 (P<0.05) hours in the bile acid content of bile, the rate of increase after the administration of 1,2,3 (P<0.01) hours of effective and positive than the control group.Conclusion:Sanjin Lidan Paishi Decoction can can increase the bile flow, has a significant role in cholagogic; can reduce the bilirubin content of bile in the free, an increase in bile acid content of bile, has changed the role of bile composition, through its choleretic effect and changes in bile composition role to achieve its role in the prevention of cholelithiasis. |
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