Col, Col. Iv, The Fn Expression In Laryngeal Squamous Cell Carcinoma With Clinical Relationship,

Objective:To investigate the expression of collagen typeⅠ(ColⅠ),collagen typeⅣ(ColⅣ) and fibronectin(Fn) in laryngeal squamous cell carcinomas(LSCC) and their pathobiological relationship with invasion and metastasis of tumor.Method:The expression of ColⅠ,ColⅣand Fn was detected by immunohistochemistry method in normal tissue of latero-carcinoma and tissue of carcinoma in 60 specimens of LSCC.Integral optical density(iOD) was detected by image analysis of computer and was analyzed by SPSS13.0.Result:The expression of ColⅠwas obvios and integrity.The expression of ColⅣand Fn of basal membrane was like intact line-shape appearance and Fn of interstitial substance appeared like a complete network in the normal tissue of latero-carcinoma. Their expression decreased gradually and their integrity was broken and disappeared gradually from well to poorly differentiated LSCC.Their expressions were also fall off with the tumor size,clinical stage and cervical lymphatic metastasis gradually and consistently in LSCC.Their variances were statistical significance separately(P<0.05 or P<0.01).Conclusion:The expression of ColⅠ,ColⅣand Fn is closely related to tumor invasion,the regional lymph node metastasis and other some pathobiological features in LSCC.A detection of ColⅠ,ColⅣand Fn was of definite significance on a better comprehension of the possibility of metastasis,choice of surgery and prognosis.