Mechanism Of Traditional Chinese Medicine Suppository Treatment Of Lumbar Disc Herniation

Objective: To observe the animals lumbar disc herniation (LDP) of the local micro-circulation changes and activation of platelet membrane (CD62P) changes in the expression, and further from the hemodynamics, cellular and molecular level low back pain Ling Shuan clarify the role of LDP mechanism, Chinese medicine treatment for the LDP reveals its pathogenesis and to explore and provide a theoretical basis.Method: monoclonal antibodies and flow cytometry, and other technology, combined with laser Doppler technology and molecular biology research on low back pain Ling Shuan mice LDP local micro-circulation and the expression of CD62P, Ling suppository in the treatment of low back pain lumbar disc herniation Of the mechanism.Results: Ling Shuan low back pain can significantly improve the mice disc and nerve root of the microcirculation, and the model group is relatively low dose group disc microcirculation difference was significant (P<0.05); sham and control groups, low-dose Group-disc cycle of high-dose group microcirculation of the nerve root There was significant difference (P<0.05). Ling suppository dose of low back pain in the mice with the model CD62p control group difference was significant (P<0.05). Hope that low back pain in the suppository doses of mouse models of chemical nerve root inflammation rectal administration for 7 days after the CD62p expression of a significant effect on low back pain Ling Shuan high-and low-dose group and the control group compared difference was not significant. Low back pain Ling Shuan 1.0, 0.5, 0.25 g Health and medicine / kg in mice to different levels to improve hemorheology indicators, compared with the model group, high-dose group whole blood viscosity, low-cut reduction of whole blood viscosity, red blood cell aggregation index Decreased significantly (compared with the model group P <0.01, P <0.05), in addition to low-dose group hematocrit, erythrocyte deformation Index TK, the other hemorheology indicators were significantly reduced role (compared with the model group P<0.05, P<0.01, P<0.001); compared with the sham group, in addition to cutting high blood viscosity reduction, erythrocyte deformation Index TK, the other hemorheology indicators were significantly reduced role (compared with the sham group P <0.05, P <0.01, P <0.001).Conclusion: The successful model of the lumbar disc herniation mouse model of its flow index, waist disc and nerve root of the micro-cycle indicators, and CD62P indicators have changed significantly. That the lumbar disc herniation with these indicators related. Hope all low back pain suppository dose group have huoxuehuayu effects, the group can be measured in the low-inhibiting platelet activation, the measurement group have significantly improved their outstanding disc ear nerve root and the microcirculation, the chemical nerve root inflammation in mice model (Simulation of lumbar disc herniation) treatment.