| OBJECTIVE: Observe and probe into, shu feng qing fei hua tan soup until chronic bronchitis acute to break out issues of tan re yu fei syndrome inTCM clinical curative effect , function mechanism and to bronchus influence that pathology damage.METHODS: Clinical study: Choose to accord with breaking out the tan re yu fei syndrome in TCM of a issue of phlegm acutely in chronic bronchitis, and accord with and include in 120 standard cases, adopt the method of dividing into groups at random, is divided into and treated 80 groups, 40 control groups. Treat group adopt, shu feng qing fei hua tan soup treatment, the control group adopts she dan chuan bei capsule treatment of bladder-like container, the course of treatment is 10 days. Observe two groups of patient's symptom physical sign, blood routine, chest X-ray, lung function and Chinese medicine card before and after treatment and wait the total mark, compare and analyse.Experimental study: Select 76 SD big mice for use, assign to the blank group at random, model group, spontaneous recovery group, shu feng qing fei hua tan soup high dosage group, shu feng qing fei hua tan soup dosage group, shu feng qing fei hua tan soup low group, and she dan chuan bei capsule group. 16 groups of model among them, other groups are 10, male and female per group are half and half. The blank group puts and raises in the environment smokelessly normally, other 6 groups adopt and improve and smoke the law to duplicate the model of big mouse of chronic bronchitis. Make the mould and succeed, irritate the stomach for 10 days, then fetch serum, lung tissue and prepare the sample, determine every group old mouse serum and lung organize TNF-a and content of IL-8 in the even thick liquid, observe lung organize pathology to slice. RESULTS: Clinical study: (1) Effect of chronic bronchitis disease showed that the treatment group compared with the rate was 57. 5%, and the total efficiency of 92.5% with the control group was 30%, and the total efficiency of 82. 5%. between the two groups was significant difference (P <0. 05), indicating that the effect of the treatment group than the control group. (2)The two groups of chronic bronchitis Syndrome effects are most notable statistical significance (P <0. 05), indicating that the effect of the treatment group than the control group. (3) The two groups before and after treatment main symptoms, signs and related Inspection Unit, the group compared with most notable statistical significance (P <0. 05), two drugs that have better effects, but the treatment group than the control group. (4) the two groups before and after the treatment group as peripheral blood, in both groups were statistically significant (P <0. 05), two drugs that can effectively improve the peripheral blood, but the treatment group than the control group.Experimental study: (1) The blank group, shu feng qing fei decoction high,medium and low dose group and she dan chuan bei capsule of serum and lung tissue of TNF-a levels compared with the model group, statistical significance (P <0. 01), natural recovery group compared with the model group, not statistically significant; (2) The blank group,shu feng qing fei hua tan decoction high,medium-dose group and she dan chuan bei capsule group, a statistically significant (P <0. 05), low dose group and Shedan Chuanbei capsule group, no significant significance of the two considerable; (3) The blank group, shu feng qing fei hua tan decoction high, medium and low dose group and she dan chuan bei capsule of serum and lung tissue of IL—8 in comparison with the model group, statistical significance (P <0. 01), natural recovery group compared with the model group, not statistically significant.CONCLUSION: Shu feng qing fei hua tan soup can significantly improve the period of acute exacerbation of chronic bronchitis tan re yu fei syndrome permit clinical symptoms, signs, Syndrome, chest X-ray and pulmonary ventilation function. Its effect may be related to inhibition mechanism, reducing airway inflammation, airway inflammation improvement of the pathological injury, and regulating immune function. |
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