Tanshinone Capsule Treatment With Clinical Research, Acne, Androgenetic Alopecia

androgenetic alopecia (AGA) .It is the common disease in Clinical Dermatology .Performance as head Temporomandibular sparse areas gradually softenedThen becamed a high loss. Some patients with temporal and at the top or most complete loss of hair,but normal hair occipital. Occur in young men, also seen in women, but less. Acne is also a disease common clinical.They both are Sebum OutflowDiseases, Both the incidence and causes of complex, But with the crew have been confirmed that it' s have an important relationship with androgen levels. Infection caused by abnormal secretion of sebum are important And increase factors both in two diseases, as a result there aways lots of With acne androgen-induced hair loss patients in Clinical Dermatology.before the large number of studies have proved that traditional Chinese medicines danshentong a significant effect with Acne. Based on similarities between the pathogenesis and cause, our research subject to through the effect of application of tanshinone treatment the With acne androgen-induced hair loss, observe whether there is a definite effect and whether it has more side effects. and the detection of serum testosterone (T) and estrogen Diol (E2) changes. Understand their hormone levels in the body. Further explore the incidence of AGA.Objective:To observe the the efficacy and side effects of capsule danshentong in the treatment of With acne androgen-induced hair loss, Through detect the testosterone (T), estradiol (E2) level and change from the patients of treatment group before and after the treatment. to know this drug impact of the hormone level.Methods:1.Clinical observation: 1.1 The source of cases and division: Selects63 example patients who came from alopecia clinic in the wuhan first hospital in February 2007 to February 2008. All example patients consistent with diagnostic code . They were divided into treatment group and comparison group by randomly. the capsule danshentong group have35 patients, and the other have 28 .1.2 General situation: The treatment group have24 males, 11 females. Age from 18-36, the average age is 28.3±6.7, the other goup have 17 males , 11 females, the average age is 30.5±5.3. Two groups have no obviously difference at ages, sexes, courses of disease and scores of prior trement (P> 0.05). They have comparability.1.3 Treatment method: We give treatment group patients capsule danshentong everyday and take orally two pills once and three times one day. And give the comparison group patients vitamin B6 10mg,tid and vitamin B2 5mg, tid for oral use.1.4 The way of observation : According to hair loss / day, the situation of greasy and Pruritus of Scalp and the growing of new hairs, At the same time were observed in patients with unusual Acne how the lesions change before and after the treatment,record down the situation monthly referral, according to the Integral to measure the effect of Standards by scoring method .assessing the overall effect,after 3monthes, At the same time observe of whether there are side effects in the process of treatment:1.5 To measure the change serum levels of testosterone(T) and estradiol (E2): 35 treatment group patients were measured the change serum levels of T and E2 before and after treatment. 3ml venous blood of subject is drawed in AM 8: 00 to 9: 00. when the women is menstrual period, her venous blood will be drawed one week after menstrual period. In post-treatment,we repeat determination. It was made use of radiative Immun to measure serum levels of T and E2. 1. 6 Statistical data: The total effective rate were examined with x², Theserum testosterone and estradiol and conditions of use of t-test scoreresults for statistical analysis.Clinical criteria and treatment results:1. Determine efficacy: this research show that, After a period of treatment,for the35 treatment group patients the cases of result significance is8(22.9%), the cases of utility is 22(62.9%), the cases of nullity is 5(14.3%) , total effective rate is85.7%; For the comparison group, the cases of result significance is 1 (3.6%), the cases of utility is 12 (42.9%), the cases of nullity is 15( 53. 6%), total effective rate is 46. 4%. reatment group's total effective rate is higher than the comparison group's, it has difference after statistics analysis (X²=12.575, P < 0.05). effects of Acne before and after treatment shows that: for the 35 treatment group patients the cases of result significance is 25 (71.4%), the cases of utility is 7(20%), the cases of nullity is 3 (8.6%) , total effective rate is91. 4%; For the comparison group, the cases of result significance is 3(10.7%), the cases of utility is 5(17.9%), the cases of nullity is 20 (71.4%) , total effective rate is 28. 6%. it has difference after statistics analysis (X² =31.783, P < 0.01).2. to evaluate scores of pathogenetic conditionIn prior treatment the scores of pathogenetic condition of both groups has not obviously difference (P> 0.05) , in post-treatment the scores of pathogenetic condition of every groups has difference to compare oneself (treatment group P< 0.01, comparison group P< 0.05). Treatment group s score is lower than the comparison group's score(P<0.01).3. The change of T and E2 before and after the treatment: For the 70 treatment groupe patients , in post-treatment the serum levels of T in both male and female patients breakdown obviously ( P < 0.01), and the serum levels of E₂ in male patients set up disobviously ( P> 0.05),but the levels of E₂ in female patients set up obviously (P<0. 01).4. the side effect of capsule danshentong : The topics in the course ofobservation found no obvious side effectsConclusion:The total effective rate and scores in post-treatment of treatment group all outstrip than the comparison group. The serum levels of T breakdown in both male and female patients, the levels of E₂ in female patients set up. And its side effects less worthy of wide dissemination.