Mountain Albizia Sedation Active Ingredients And Quality Of Analysis And Research

Albizia kalkora(Roxb.)Prain was from Leguminosae.It can resist tumor,enhance immune,mitigate and antifertility.It was the substitute of Cortex Albizziae on clinical.The currently pharmaco-experiment research made clear that Albizzia julibrissin Durazz and Albizia kalkora(Roxb.)Prain had the samebiological activity about mitigating.Albiziakalkora(Roxb.)Prain had abundant abundant and parv-noxious.The dissertation researchedon its sedated material base and quality evaluation system,providing science principle on exploitation and utilization the medicinal plantUnder the pursuit of pharmacology,deploied the system solvent method to abstract Albizia kalkora(Roxb.)Prain in different polar extract.Definited the n-butanol extract was the active part; deploied silicagel stratography,we abstracted the n-butanol extractive in four fraction,luther definited the active part.11 constituents were isolated from its n-butanol fraction by various kinds of chromatographies.9 of them were identified,their chemical compound's name were as follows:(-)-syringaresinol-4-O-β-D-glncopyranoside (â… ),(-)-syringaresinol-4,4'-bis-O-β-D-glncopyranoside (â…¡),icarside E5(â…¢),L-2-piperidinecarboxylic ac id(â…£),6,6'-(ethane-1,2-diylbis(oxy))bis(5-methoxycyclohexane-1,2,3, 4-tetraol)(â…¤);(-)-syringaresinol -4-O-β-D-apiofuranosyl(1â†'2) -β-D-glucopyranoside(â…¥);Tricosane(â…¦);1-methoxy octadecane(â…§); (-)-syringaresinol-4-O-β-D-apiofuranosyl(1â†'2)-β-D-glncopyranoside-4'-O-β-D--glncopyranoside (â…¨).they were isolated for the first time from Albizia kalkora(Roxb.)Prain.Used contemporary pharmaco-method,We sieved the active chemical s from above-mentioned compound,finding(-)-syringaresinol-4-O-β-D-glncopyranoside had obviously conscious-sedation activity.Thus we provid base for annotating sedated materia foundation of Albizi akalkora(Roxb.)Prain.Deploied contemporary analytical method,referenced the normalization medical material quality specification in《Chinese Pharmacopoei a》2005 edition,we systemly studied its character,micro-appreciation, lamellar appreciation,moisture content and heavy metal check,content measure,et al.Institute fairly consummate of quality specification; according to《specification of traditional Chinese medicine injectable preparation fingerprint》which promulgated by SFDa,instituted the fingerprint of Albizia kalkora(Roxb.)Prain,standardizated 25 ownedpeaks.The chromatographic peaks had good resolving power,high similardegree,hadro- authenticity device.Thus we established quality evaluation system of Albizia kalkora(Roxb.)Prain as international specification.