Tetramethylpyrazine Salvia Injection In Treating Migraine Blood Stasis Obstructing The Network-based Clinical Research

Objective:The migraine is one kind of chronic nerve blood vessel disorderdisease,is by fills the air the nature or the single side manifestssuddenly, theache is fierce, repeatedly sends takes thecharacteristic one kind ofclinical common disease, thefrequently-occurring disease. The overseasmaterial demonstrated that, the migraine disease incidence rate female is12.9 %～17.6%, themale is 3.4%～6.1%. The epidemiology investigationindicated that, our country migraine prevalence rate is 985. 2,/10 tenthousand, theyear disease incidence rale is 70. 7,/10 ten thousand. Thisgets sickrepeatedly manifests suddenly procrastinates difficultly torecover, creates the enormous pain to the patient, is always regarded asby themedicine the difficult sickness. Therefore, has become one Ofmedicineattention hot spots to the migraine pathogenesis and its thetreatmentmedicine research.The migraine method of treatment may divide into the medicine andthenon-medicine treats two kinds. The medicine treatment may divideintotwo kinds, its one is regardless of the migraine manifests suddenlyornot takes every day reduces manifests suddenly the frequency andreducesthe ache degree the preventive treatment. Second is themigraine manifestssuddenly the time treatment. The latter kind oftreatment medicine mayfurther divide into the migraine specificityand the non-specificitymedicine. The non-specificity medicinething-in-itself, to the acetylamino acid, the non-cerebral cortex steroid anti-inflammation medicine,thepreparation and union and so on is used for to treat themany kinds ofaches disease. The specificity medicine including theergotamine, thedouble hydrogen ergotamine and Qu Tanlei, they caneffoctivoly treat themigraine and the crowding together headache, butis different to treatsother types the ache.Headache carries to "In Passes through", is positive, compressed-airdriven, the phlegm anti-, the stasis stagnates for themigraine mainpathology factor. In this gets sick manifests suddenlyin the process bothto be possible alone to appear, and may the mutualinfluence, the cause andeffect relationship. Because phlegm anti-stagnation of flow of vital energythen the blood winds the easystasis, the stasis stagnates the vitality thenthe phlegm is easyto remain, the common cold always concurrently pinchesthe phlegm on harasses, the phlegm stasis each is easy toborrowcompressed-air driven creates disaster. The migraine cause ofdiseasealthough has all sorts of is different, but it pathogenesis reallyhasthe something in common, namely so-called "not general rule pain", butinits degree and the nature respectively has its characteristic andthe difference, this has provided the basis for the clinical diagnosisandmillenniums the development, to be many through the diagnosisand treatmentto the difficult card treatment may attain a bettereffect. This topic isfor the purpose of through the clinical observation, theresearch havinginvigorates the blood, passes winds stops painthe effect rhizome ofLigusticum wallicbii salvia miltiorrhizainoculation fluid to treat themigrainethe anti-windingclinical curative effect and the security.Method:1, case of illness elects from from January, 2006 to March, 200760examples migraine which receives a medical examination in theHubeiProvince Chinese medicine hospital outpatient service and.thehospitalward瘀血the anti-winding patient, uses stochastic, theparallelcomparison method, the treatment group andthe comparisongroupaccording to 1: 1 proportion, stochastically divides into therhizomeof higusticum wallichii嗪salvia miltiorrhiza inoculationfluidtreatment group and the injection with the methylsulfonic aciddihydroergot alkali freezing and drying powder comparison group, eachgroupof 30 examples, give the medicine in turn according to the serialnumber,continuously uses medicine 15 day is a treatment course, hadfinished afterthe medicine carries on the curative effect toevaluate. Method of treatment:Treatment group medicine for rhizome ofLigusticum wallichii嗪salviamiltiorrhiza inoculation fluid 250mlvein drop note, every day, withmedicine 15 days. The comparison groupmedicine uses the methylsulfonic aciddihydro ergot alkali freczingand drying powder 0.3mg+5%GS250ml vein dropnote for the injection, every day, with medicine 15 days. Treatment periodstops using othertreatment headaches the medicine. Before two groups treatstop usingall pain-killers.2, the secure examination project is the first diagnosis first dayand15th days respectively makes a time of laboratory inspectionaround thetreatment after the medicine,, the routineurine test, the excrementconvention, the hepatorenal function, theelectrocardiogram took the securetarget, determined the rhizome ofLigusticum wallichii salvia miltiorrhizainoculation fluid iswhether virulent, the side effect.3, treatments is the first diagnosis first day and experimentslst dayafter the medicine, 7th days, 15th days respectively observesa recordmigraine clinical symptom curative effect integral, thestroke symptomgrades, and makes statistics processing, uses themethylsulfonic aciddihydro ergot alkali freezing and drying powdertwo medicines compared with the rhizome of Ligusticum wallichii salvia miltiorrhiza inoculation fluidand the injeetion the eliniealeurative effeets.Result:1, migraine clinical symptom curative effect determination analysis:After the treatment clinically treats the group to cure the populationis4 examples, shows results the population 15 examples, theeffectivepopulation is 8 examples, the invalid 3 examples, thetotaleffectiveness is 90.00%; The comparison group clinical curesthepopulation is 3 examples, shows results the population 14 examples, theeffective population is 8 examples, the invalid b examples, thetotaleffectiveness is 83.33%. After the Ridit examination, thetreatment groupand the comparison group may improve the migraineclinical symptom curativeeffect, two groups of curative effectscomparisons does not have显著性thedifference (p＞0.05). Explained the rhizome of Ligusticum wallichii嗪salvia miltiorrhizainoculation fluid has the distinct improvement functionto themigraine clinical symptom.2, Chinese medicine symptoms curative effect evaluates the analysisAfter the treatment clinieally treats the group to cure thepopulation is8 examples, shows results the population is 13 examples, the effectivepopulation is 5 examples, the invalid 4 examples, thetotal effectivenessis 86.66%; The comparison group clinical cures thepopulationis 8 examples,shows results the population 14 examples, effective population 3 examples,invalid 5 examples, totaleffectiveness 83.33%. After the Ridit examination,after the Riditexamination, the treatmept group and the comparison groupmay improvethe Chinese medicine symptom, two groups do not havethoditference after statistics examination (p＞0.05). Explained therhizomeof Ligusticum wallichii salvia miltiorrhiza inocutationfluid has thedistinct improvement function to the Chinese medicinesymptom.3, secure examinations: After the secure examination, observes thepatient blood, the urine, the excrement convention, the excrement dives theblood inspection, the electrocardiogram, the hepatorenal function,demonstrated therhizome of Ligusticum wallichii salvia miltiorrhizainoculationfluid non-toxic, the side effect, the use security, thecurativeeffect is reliable.Conclusion:The rhizome of Ligusticum wallichii salvia miltiorrhizainoculationfluid and the injection treats the migraine Chinesemedicine symptom withthe methylsulfonic acid dihydro ergot alkalifreezing and drying powder torecord points, the migraine clinicalsymptom synthesis grades afterstatistics analysis comparison does nothave the difference (p＞0.05). Simultancously passesthrough the sceure examination, demonstrates thismedicine non-toxic, the side effect, The result indicated that, rhizome ofLigusticumwallichii salvia miltiorrhiza inoculation fluid non-toxic,sideeffect, safe is reliable. Above explained the rhizome of Ligusticumwallichii salviamiltiorrhiza inoculation fluid to the migraine patient'sChinesemedicine symptom, the migraine clinical symptom has theobviouscurative effect, also use security, non-toxic, side effect.