Chest Meridians Soup Treatment Of Unstable Angina Clinical Studies

Objective:Study of unstable angina Kuanxiongtongluotang (KXTLT) clinical efficacy andsafety. Combining traditional Chinese and western medicine treatment of unstableangina explore effective ways. Confirm unstable angina tanyuzuluo Syndromeobjectivity1 Methods:Treatment Methods: 92 patients were diagnosed with unstable angina, and thedialectic of tanyuzuluo Syndrome Patients. Random number tableKuanxiongtongluotangrandomly divided into the treatment group (group A) andWestern conventional therapy group (group B), each of the 46 cases. Control groupusing conventional western medicine treatment: Aspirin 100 mg oral qd;Isosorbide Mononitrate qN oral 40mg; Atorvastatin qN oral 10mg; Betaloc6.25-25mg, qd, oral dose of the individual, without any medicine, includingproprietary Chinese medicines. Chinese medicines, such as injections, treatmentgroup treated with soup Kuanxiongtongluotang and Conventional Westernmedicine, 300ml Bid. Preparations Preparation Room production by Wuhanhospital. Under conditions of timely adjustments to maintain the heart rate 55-70beats per minute. With angina attack may serve Isosorbide Dinitrate 5mg, theserious use 40mg Isosorbide Mononitrate injection add to the 5% GS to Infusion。2 Observation methods and indicators: A total of 4weeks treatment. All cases tobe examinated in the two days of observation and be completed within one weekafter the end of the relevant physical and chemical examinations, such as blood,urine, it conventional, biochemical (liver function, kidney function, blood sugar,cholesterol, electrolytes, blood rheology), electrocardiogram ECG, left ventricularejection fraction and left ventricular fractional shortening, E/A value, completinginformed consent. In the treatment, observes the related Tradtional Chinesemedicine symptoms as if chest pain, the chest stuffy, the palpitation, feels weak,short gas,abdomen local ruffian full, the four limbs are heavy, the change of tongueand pulse.and so on, To record the possible side-effect,such as tetter, the reaction alimentary tract, arrhythmia, hypotension, the decrease of blood platelet,albuminuria, liver and kidney toxicity. To record the changes of body signs everyone week, such as pulse, breath, blood pressure, the weight of the body,cyanopathy, rhythm of the heart, heart rate, heart sound, heart murmur, breathsound, rale, ambulant sonant, the thing of liver and spleen, edema. At the sametime, record the days of patient in hospital and the use thing of drug every day.3 Statistical methods: Measurement data using the unpaired Student's t test,chi-square test or measurement data using Wilcoxon test, grading information isRidit analysis. SPSS13.0 software statistical calculations to be completed. Riditanalysis using Excel 2003 and the completion of the software.Results.1 The rate of distinctive effect of group A was 56.52%, the total effective rate was91.30 %; that of group B was 39.13 %, the total effective rate was 71.74 %. Therewas distinctive difference between groups by statistical analysis (P＜0.05).2 TCM symptom scores after treatment than before treatment groups significantlyimproved (P＜0.01). However, the treatment group decreased significantlycompared with the control group (P＜0.01).3 Specific improvements in Tradtional Chinese medicine symptoms, treatmentgroup of chest pain, chest tightness, abdomen local ruffian full,the four limbs areheavy, the change of tongue and pulse and so superior to the control group (P＜0.05or P＜0.01).4 Heart function, ejection fraction in the two groups after treatment, E/A weresignificantly improved after treatment (P＜0.05). However, the treatment groupcompared with the control group improved significantly (P＜0.05).5 Aftertreatment,serumlipids(totalcholesterol,triglycerides, high-density lipoproteinHDL,low-density lipoprotein LDL) were significantly improved compared withthose before treatment (P＜0.01). However, the treatment group improvedsignificantly more than the control group (P＜0.05or P＜0.01).6 After treatment, the blood rheology (whole blood viscosity, plasma viscosity andwhole blood viscosity, high shear rate, Low shear rate blood viscosity) indicator (than before treatment were significantly (P＜0.05or P＜0.01).However, thetreatment group improved significantly more than the control group (P＜0.05 or P＜0.01).7 Safety Analysis: the course of treatment, although the two individual heart rate, but after the adjustment Western consumption will be corrected. Although the useof Chinese medicine treatment in the early individual anorexia, but not serious anddisappear. Treatment, All patients in both groups had no rash, thrombocytopenia, Hypokalemia disorder, among others. After treatment, patients in both groups hadno significant kidney and liver damage and serious arrhythmiasConclusion:Treatment of unstable angina Kuanxiongtongluotang with conventional Westernmedicine have synergistic effect, not only can increase the effects myocardialblood supply, stable condition faster, better, improve the exercise tolerance. Inaddition, no significant side effects Kuanxiongtongluotang, good safety.Meanwhile, the results of this study have confirmed the tanyuzuluo is an importantobjective unstable angina syndrome.