Mole Clinical Performance Of New Features

OBJECTIVE :To investigate the Changes of the clinical features of hydatidiform mole.MATERIALS AND METHODS : one hundred and thirteen cases of hydatidiform mole treated in Peking Union Medical College Hospital during 1989 -2006 were reviewed retrospectively and a comparison was made to historic data ( 1948-1975 ) using X~2 test.RESULTS: The median age was 28 years(ranges from 20 to 55 years). The median gestational age was 90.2 days. Vaginal bleeding remaines the most common presenting symptom, ocurring in 94 of 113 cases (83.2%) . Filly-two of 113 cases(46% ) presented with excessive uterine size. Preeclampsia ,hyperemsis , hemoptysis and theca lutein cysts occurred in 4 of 113(3.5% ),12 of 113( 10.6% ),4 of 113 (3.5%) and 19 of 113 cases ( 16.8% ) respectively. Incidence of postmolar trophoblastie neoplasia was 21% (24 of 113 ) . Campared to historic data,the incidence of vaginal bleeding and preeelampsia were statistically lower(P＜0.005). The incidence of postmolar trophoblastie neoplasia was increased moderately without statistical significance compared to historic data.CONCLUSIONS : Because of the wide use ofultrasonography and serum hCG test , current patients with hydatidiform mole .has been diagnosed earlier in gestation and the clinical features has changed. Patterns of medical practice should be changed ,too.