Hypertrophic Cardiomyopathy Of The Left Ventricular Outflow Tract Obstruction And Cardiac Hypertrophy-related Genes In Bioinformatics Research

Even carrying an identical gene mutation, inter- and intra-family variations between noticed worldwide in the presence and the severity of left ventricular outflow obstruction and left ventricular hypertrophy in patients with hypertrophic cardiomyopathy (HCM). Modifier genes may contribute to the diversity. Which modifier gene is responsible and how many are involved is still unknown. Angiotensinogen (AGT) gene polymorphism has been associated with cardiac hypertrophy. We hypothesized that AGT gene polymorphism may play a modifier role in the diversity of left ventricular outflow obstruction. To test the hypothesis, we genotyped the polymorphism of AGT gene in HCM patients of 225 with or without left ventricular outflow obstruction and 243 age-and sex-matched healthy controls. The polymorphism of A/G in 3'un-translated region of AGT gene was genotyped. We found that the frequency of A allele was higher in patients than in controls (51.2% versus 35.8%, p＜0.05), and the GG genotype was lower in patients than in control (49.8% versus 64.2%, p＜0.05). The patients carrying A allele had a higher proportion of left ventricular outflow obstruction (30.1% versus 17.0%, p＜0.05) and more proportion of heart failure (NYHA functional classⅢ～Ⅳ, 35.4% versus 18.8%, p＜0.05) than those carrying GG genotype. After adjusted to age at diagnosis, sex, interventricular septum, family history of HCM and family history of sudden death by using multiple regression analysis, the A allele confers 2.4 fold risk for left ventricular outflow obstruction than GG genotype (adjusted OR=2.4, 95%CI 1.2 to 4.8). Our data indicate that A allele of AGT might be a genetic contributor for patients with HCM to develop left ventricular outflow obstruction. Human being has entered a bio-century, biochip shows great importance in genetic research and clinical diagnosis. Now, biochip has been recognized as one of the greatest inventions of human history. The genes down-regulated in patients with HCM or DCM were analysed from dchip2005.