The Immunological Mechanisms Of Tcm Syndrome Of Protracted Withdrawal Syndrome

Recently, the extrinsic opioid dependence ( for example morphine, acetomorphine) has become serious social problems and the drug abuse has also become the global social effects to pollution. Drug prohibiting and drug refraining have become a focus to which have been payed close attention by medical science and society . Long-term opium taking will result in damaging to the function of organ in human body and innate immunity, the liability of many kinds of disease, especially destroying the function of stomach,liver,heart,brain,overdosing on opium still can lead to death.Opioid dependence and abstinence looks like Twins, dependence manifests abstinence. Detoxification is not very difficult ,but, there are no effective measures to solve the problem of Protracted abstinence symptom of opium-addicts, so the disease of opioid dependence is difficult to cure and is following with interest. TCM laid stress on accommodation entirety and determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs, a mild effect, adapting to long-term use, the mechanism of action possessed distinct superiority to extensively pathological damage and relapse rate.Opioid dependence leads to neuropsychic disequilibrium. Not only lowering the power of resistance, but also affecting the patient in psychology. It is known to all, the substance depilatory sufferer is so weak that they are liabile to have various kinds disease. In the same time, they are always depressed,anxious. In order to approach an effect of the syndrome of Protracted abstinence symptom, especially the characteristic of immunology on TCM syndrome of Protracted abstinence symptom, this experiment adopt the method of combining illness witn syndrome to make the animal models, differentiation of symptoms and signs by means of asthenia and sthenia, so as to acquiring the base of immunology on different syndromes of Protracted abstinence symptom.Acetomorphine does harm to physical and mental health in human body, then addicts is liable to have infectious diseases. But the report on the population immune function is less, so we select the Traditional Chinese Medicine syndrome of Protracted abstinence symptom of opium-addicts and the mechanisms about immunology, basing on the theory of TCM and the advance of modern immunology and integrating the related data and the results of modern theory experiment,clinical research. In order to discover acquiring the base of immunology on different syndromes of Protracted abstinence symptom.Theoretical Studies:In this part, the paper studied the Chinese traditional medicine documents on detoxification and exploration of the types of Chinese traditional medicine syndromes of protracted withdrawal symptoms and the modern medicine documents. Then go deep into the emphases of this study—TCM syndrome of protracted withdrawal symptoms and the feature of amynology.Clinical Studies:Drug taking not only damages physical and mental health in patients, but also destroys their family and society. We found that the factor of sex affected syndrome more or less according to the study on 1000 drug addicts. the reason is probably that there are difference in the body constitution and immunity between male and female, the symptom-complex is discrepancy though the pathogenetic condition is identical. So we choose the contrast in male and female as the starting point of the study.1 Changes in protracted withdrawal symptoms after detoxification 1000 heroin addicts with drug free for 15-120 days after detoxification were rated with self-designed'chinese medicine syndrome questionnaire'.The result indicates that scores of sleep disorders,anxiety and body symptoms declined slowly within 15-120 days after detoxification.scores of memory fluctuated most apparently among the Protracted abstinence symptom of opium-addicts, Anxiety, insomnia and weariness was the second important symptom in heroin addicts after detoxification.2 Investigation PDA on sex differences in demography and abusage condition Drug taking has become a focus following by the world, dope abuse is serious in our country. The mode of drug refraining is too single to confront with more and more drug addicts. On the basis of the condition, the study analyses the different feature of male and female, in order that we can provide individual character rehabilitation modality with our information. However, the male and female have physical and mental sex differences, so ther are changes in protracted withdrawal symptoms. The study based on large scale clinic investigation, analyzing the protracted withdrawal symptoms of male and female by operating statistics software , in order to educing the ascendancy in TCM, gaining a better curative effect.Experimental Studies:The experiment established a good method of model making according to the improvement of succeed method in pertinent literature. Combined illness with syndrome can imitate the characteristic of the symptom-complex. the study measured the rat models by using open field and the consequence proved that the experimental model making was done well.1 Rat model for morphine dependence 1.1 Rat model for morphine dependence According to our finished method, rats were given in gradually increasing doses of morphine to produce physical dependences. 1.2 Rat model for syndrome and complex model (1)Deficiency of vital energy Circumscribing food and drink, half forage volume 5 days. Otherwise, swimming everyday and taking out of rats from aqua till animals sinking.'exhaustion fades pneuma', excess of exertion can cause deficiency of vital energy. (2)stagnantion of pneuma Investigation indicates that foreseeing stress should not cause escape or change of behavior. Accordingly, in order to refraining from accommodation we apply kinds of method. include:swimming in ice water,thermal stress,alimentary abstinence,water breakdown,day and night perversion,clamping tail. It is more reasonable of make stagnantion of pneuma model. From 6th , making rat for morphine dependence 12days meanwhile making model for syndrome.2 The research on behavioral exploration of the impact on the ability of learning and memory of addiction and treated rats Detecting ethology by using open field can reflects that excitability, adaptability ,probing of animals. Cognitive ability of animal and ability of accommodating circumstance decreased , but exploratory behavior increased obvioursly. It proved that deficiency of vital energy,stagnantion of pneuma and morphine dependence may result in immunity of rat cutting down,adaptability and cognitive ability of space decreased apparently.3 The research on the index numbers of thoracic gland and spleen in rat modelsThe index numbers of thoracic gland and spleen are the important signal of the functions of thoracic gland and spleen,so the change of index numbers can reflect the condition of immune function. The study intended to find that the alteration of syndrome of Protracted abstinence symptom of opium-addicts in immunology. The result indicated that morphine dependence group was lower than normal group, morphine dependence and combined illness with symptom-complex was more lower.Conclusion: Morphine dependence harms the immune function.4 The research on cell factor of Th1/ Th2 in Morphine dependence rat models and stagnantion of pneuma plus Morphine dependence rat models.Determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs is quintessence of treatment in TCM. The foundation to realize theory conjugated between TCM and medicine. We can find easily that syndrome is the reflection of multisystem functional change in nerves,endocrine secretion,immunization, therefore, the essence of syndrome should be the reaction based of juncture all around changed with disease. So we adopt model making combined illness with syndrome in order to find the immunology alteration while different syndrome showed up.The result indicated that cell factor TH1 in Morphine dependence rats was lower than normal, while cell factor TH2 was higher, the result about the disequilibrium in Th1/ Th2 was Th2 predominating. Hinting that long-term drug abuse can restrain cytoactive Th1, cutting down the degree of cell immunity.Cell factor TH2 in Stagnance of pneuma rats was lower than normal,while cell factor TH1 was higher, the result about the disequilibrium in Th1/ Th2 was Th1 predominating.5 The research on IgA,IgE,IgM in Morphine dependence rat models and combined illness with syndrome rat models.We apply ELISA for IgA,IgE,IgM in groups in order to find the relation the withdrawal syndrome and immune function.Conclusion : IgE in Morphine dependence group is higher, IgA in Morphine dependence group is lower, IgM in Morphine dependence group is higher.6 The research on HT cAMP,cGMP Stagnantion of pneuma model and combined illness with syndrome rat models.The change of cAMP,cGMP in stress reaction reflected physiological and pathological state alteration. The experiment found that chronic psychological stress would make the content of HT cAMP,cGMP ignificantly increased.