The Chicken Pineal Gland Removal Of The Animal Model Of Scoliosis Pathogenesis

Objective: 1. To prove the role of melatonin in the pathogens of chicken scoliosis induced by pinealectomy. 2. To characterize the scoliosis produced in young chickens after pinealectomy and to compare these characteristics with those seen in human patients with adolescent idiopathic scoliosis. 3. Based on this research, we forward the pathogenesis of chicken scoliosis induced by pinealectomy. Material and methods: Pinealectomy was performed on 20 chickens to induce scoliosis and achieve low level of melatonin. Constant light was used to achieve low level melatonin in chicken serum. Radiology on chicken spine was had monthly for scoliosis in both groups. The characteristics of scoliosis produced in chickens after pinealectomy were measured from radiographs and descriped in anatomy and chemohistology when the chickens were sacrificed at three-month-old. Results: In the 20 pinealectomized chickens, scoliosis was found in 11 chickens. The cobb?angle was 11-85, are 17. % Al tLuugh constant light can achieve hysiologic pinealectomy?fr secretion of melatonin, it cannot induce scoiosis in chicken. The characteristics of chickens?scoliosis were three dimensions spinal deformity with kyphosis in sagittal plane, scoliosis in coronal plane and ratotion in its axis. The vertebral body in the convex was higher than the concave side and the anterior edge higher than the posterior. 3 Conclusions: 1. Although pinealectomy can induce scoiosis in chicken, its pathogenesis is not through suppressing secretion of melatonin. 2. The characteristics of chickens?scoliosis induced by pinealectomy were similar to the changes in adolescent idiopathic scoliosis. 3. The study of the chicken scoliosis pathogensis may do some contribute to the etiology of human IS.