Evodia Medicinal Quality, Pharmacokinetics And Tissue Distribution Studies

Purpose: Based on the basic theory of TCM as the guide, combining modern science and technology, the quality of TCM Evodia rutaecarpa comprehensive standardized research. compared the quality of Evodia rutaecarpa from different habitats and different processed products。Build a more perfect quality standards for guiding clinical drug and provide theoretical basis for basic research。Materials and methods: TLC method of Chinese medicine in Evodia rutaecarpa the identification research,;by orthogonal design to confirm the best extraction conditions of Evodia rutaecarpa;UsingHPLCmeasurement method ,simultaneous deter the contents of evodiamine, rutaecarpine and Evodine; and do high-performance liquid fingerprints research in Chinese Evodia rutaecarpa; studies the pharmacokinetic and the distribution of the organization of traditional Chinese Evodia rutaecarpa.Results:1. This method of Evodia rutaecarpa of medicinal TLC identification, spots clear , separating degree, Rf value and method repeatability and specificity were good.2. By HPLC method , determine the main contents of Evodia rutaecarpa, the linear relationships, precision, stability, repeatability and recovery are standard.3.Confirm the best extraction conditions of Evodia rutaecarpa: namely ethanol extraction solution concentration for 16 times as much as 70%, solvent quantity, extracting time 1.5h, extract three times.4.Research high-performance liquid fingerprints research in Chinese Evodia rutaecarpa. 5.Research the pharmacokinetic and the distribution of the organization of traditional Chinese Evodia rutaecarpa.Conclusion:Through the study of traditional Chinese medicine Evodia rutaecarpa, comprehensive standardization, determines the quality of Evodia rutaecarpa multi-index composition determination, perfecting the system of quality standards, the drug for the further research and development of Evodia rutaecarpa.