| Purpose:Observes the bitter dish drinks to the unstable angina pectoris (lacking in vital energy blood stasis card) the clinical curative effect and the security and discuss its curative effect mechanism, builds the foundation for the clinical promoted application. Material and method:1 Clinical Date: December, 2009 to December, 2010 period, from in Dalian Chinese medicine hospital Heart Internal medicine department's in-patients, will refer to "Traditional Chinese medicine New Medicine To treat Coronary disease Angina pectoris Clinical research Guiding principle" (in 2002 version) and in 2007 the China Medical Association cardiovascular disease school grades will announce "Unstable Angina pectoris And the Non-ST Section Raises Heart Stem Diagnosis And Treatment Guide" chooses conforms to the unstable angina pectoris painstaking care stasis anti- card diagnosis 40-75 year-old patient 82 examples to take the object of observation. Divides into the treatment group completely stochastically (the n=42 example) and the control group (the n=40 example)2 Drug Administration:Divides into the treatment group completely stochastically (the n=42 example) and the control group (the n=40 example) treats the group to add in the conventional western medicine treatment foundation with has the blood circulation removing extravasted blood effect bitter dish to drink (in courtyard preparation), 1 medicinal preparation, divides two clothing every day; The control group gives the conventional western medicine treatment. Merge diabetes, hypertension and other diseases give the corresponding doctor practicing western medicine to treat, when angina pectoris outbreak the hypoglossis contains clothing blasting oil 0.5mg, two groups of treatment courses are 14 days. Simultaneously enjoins the patient to treat the period attention rest, the light diet, envies the tobacco and liquor.3 Observing Indexes:Observes two group of patients treat the period heart rate, the blood pressure and so on ordinary circumstances, around the medication the angina pectoris outbreak number of times, the duration, the alleviation time and the electrocardiogram, the blood fats and the inflammation factor (C RP) change.4 Statistical Analysis:Different pick x2, the T-test, the variance analysis, the Ridit analysis separately according to the observation target and the data and so on corresponding statistics processing.Results:1 symptom comparison: After the treatment group treats, the symptom has the distinct improvement, after the control group treats, only the partial symptoms has the improvement, after two groups treat, the comparison has the remarkable difference. 2 electrocardiogram comparisons: The treatment group electrocardiogram obviously efficiency is 23.8%, the total effectiveness is 71.43%; The control group obviously efficiency is 5%, the total effectiveness is 50%; Around the treatment has the dynamic electrocardiogram material treatment group 36 examples, the control group 34 examples. Treatment group dynamic electrocardiogram effectiveness is 47.2%, the total effectiveness is 69.5%; Control group dynamic electrocardiogram effectiveness is 20.6%, the total effectiveness is 41.2%.3 have the complications patient comparison: And has hypertension regarding two combinations, the diabetic, the treatment group curative effect surpasses the control group.4 around use the echocardiogram to determine the patient to treat targets and so on SV, CO, CI, EF, E, A, E/A. After the result treatment group treats, the heart function distinct improvement, the comparison has the significance difference before the treatment(P<0.01); After the control group treats, sv, CO, CI, EF have the improvement(P<0.05), but E, A, the E/A improvement is not obvious. After two groups treat the comparison, CO, CI, EF, E/A have the significance difference(P<0.01或0.05).5 Blood platelet activated molecule comparison; Before two groups treat, compare CD62P, CD63, the IECa2+ not remarkable difference(P>0.05), after the treatment group governs, contrast before the treatment have the significance difference(P<0.01), but after the control group treats, compares CD63 before the treatment to have the obvious difference(P<0.05), CD62p and the IECa2+ not obvious difference(P>0.05), after two groups treat, compares CD62P, CD63 and IECa2+ has the significance difference(P<0.01或0.05).6 Hepatorenal function change comparison: Around the treatment the ATL, Cr, BUN three targets are not remarkable change(P>0.05).Conclusion:The bitter dish drinks the treatment unstable angina pectoris (lacking in vital energy blood stasis card) the clinical curative effect to affirm, but alleviates the angina pectoris effectively, the improvement electrocardiogram, the alleviation Chinese medicine card marquis, has certain bast protection function and has the good security. |
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