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The article 357 in the Jueyin disease of "Shanghan Lun" is about the syndrome and treatment of the mahuang shengma decoction, which is the deteriorated case and mistreated syndrome of intermingled cold and heat, deficiency and excess, caused by purgative errors and wrong treatment. The syndrome is upper heat and lower cold, upper excess and lower deficiency, and Zhongjing called it "intractable". Mahuang Shengma Decoction cures the syndrome of pulmonary heat and splenic cold. The decoction nourishes yin and tonifies blood, harmonizes yingfen and weifen, and is well considered in every respect.This study is divided into four parts. The first part is the literature review, to outreach the concept of the Mahuang Shengma Decoction syndrome, and all kinds of applications by learned physicians for generations. Zhongjing believed that we should treat the Jueyin disease carefully, and treat the damaged Yin and Yang by considering carefully the amount of the dosage. And the Mahuang Shengma Decoction is well considered in every respect.The second part discusses the Mahuang Shengma Decoction's characteristics of the etiology, pathogenesis, syndrome, and clinical application. And the impact on future generations. We will discuss the curative effect, based on the physiology and treatment of modern medicine.The third part is studying the ingredient, synergy, and the decocting and taking method of Mahuang Shengma Decoction. In the "Shanghan Lun", whether there is such a recipe of Mahuang Shengma Decoction or not, still have a lot of controversy nowadays. Though the prescription seems messy but actually in order. It combines the tonic, purgative, cold, and warm formulas. Sovereign drugs and minister drugs are in order. By warming the spleen and clearing the lungs, it harmonizes the yin and yang, yinfen and weifen.The fourth part is the clinical applications of Mahuang Shengma Decoction' s prescription and syndrome. We study the clinical case of modern application of this prescription, in the zangfu viscera way, the yin damaged by purgative errors, causing the "upper heat" such as the stagnant heat in the lung, ill throat, and spit the pus and blood; and the "lower cold" such as dysfunction of spleen, diarrhea. Through the syndrome differentiation of six channels theory. The yin and yang are the general principles, and the Taiyang, Yangming, Shaoyang, Taiyin, Shaoyin, Jueyin are the guiding principles. The research of Mahuang Shengma Decoction is conducive to the developing of Zhongjing's theory, and the inheritance of TCM. It is also good to spread out the studies of the clinical and basic TCM.