Spleen Dampness, Phlegm And Promoting Blood Circulation Treatment Of Nonalcoholic Steatohepatitis Clinical Observation

Objective As the major pathogenesis of non-alcoholic steatohepatitis is Spleen eficiency and wet-sheng complicated with stasis and phlegm, the treatment is nutriting the spleen and dispelling dampness, resolving phlegm and accumulating blood.We formulated basic prescription, and the herbal medicines were modified according to different clinical symptoms, to observe the clinical efficacy of the treatment of nourishing the spleen and dispelling dampness, resolving phlegm and accumulating blood, verifying the major pathogenesis of Spleen deficiency and wet-sheng complicated with stasis and phlegm, verifying the treatment of nourishing the spleen and dispelling dampness, resolving phlegm and accumulating blood,exploring the safe and effective therapy and drug for the treatment of non-alcoholic steatohepatitis by traditional Chinese medicine.Methods 63 patients diagnosed with non-alcoholic steatohepatitis and chosen by adoption standards were randomly divided into two groups (treatment group 31 cases and control group 32 cases). The therapy of treatment group was nutriting the spleen and dispelling dampness, resolving phlegm and accumulating blood. The basic prescription form:Fried white atractylodes 15 g, Poria cocos 15 g, Twisted strands of aram 10 g, Alisma orientalis 20 g, Hang basin grass 30 g, Grass JueMing 10 g, Turmeric 10 g, Salvia miltiorrhiza 30 g, White mustard 10 g, Health hawthorn 15 g. Radix 10 g and ZhiKe 10 g was plused for the patients with the stagnation of Liver-Qi syndrome, Unprocessed Shouwu 15 g and Medlar 15 g was plused for the patients with Liver and kidney deficiency. Oral 200ml/times,2 times/day. The control group took western medicine Essentiale, Oral 2 grain (456mg)/times, three times per day.Two groups were treated for 3 months.Diet and exercise interventions were given,The doctor Guided rational diet, exercise for patients and formulated diet and exercise observation form, Asking patients to truthfully report and record their diet, exercise situation weekly. The clinical effect of those two groups were compared by observing liver enzymology (ALT, AST, GGT), abdominal CT, syndrome curative effect and single symptom scores.Results 1. The curative effect of liver enzymology:In improving ALT:The total effective rate of the treatment group was 70.4%, Compared with before treatment, ALT dropped significantly, difference was statistically significant (P< 0.05); The control group total effectiveness was 40.7%, ALT decline was not obvious, the difference was not statistically significant (P> 0.05); The total effective rate of the treatment group was higher than control group, the difference was statistically significant (P<0.05). In improving the AST, GGT aspects:before and after the treatment, two groups were not significantly drop within the group and between groups, there were no statistically significant difference (P> 0.05).2. The curative effect of Abdominal CT:The total effective rate of the treatment group was 33.3%, and the control group was 18.5%, the difference of two groups compared with before treatment was not statistically significant (P>0.05); The total effective rate of treatment group was better than control group, but the difference was not statistically significant (P>0.05).3. The curative effect of syndrome:The total effective rate of the treatment group was 92.6%, compared with before treatment, Syndrome improved significantly, the difference was statistically significant (P< 0.05); The total effective rate of the control group was 74.1%, compared with before treatment, Syndrome improved significantly, the difference was statistically significant (P<0.05); The total effective rate of treatment group was better than control group and the difference was statistically significant (P< 0.05).4. The curative effect of single symptoms:Both groups could improve single symptoms such as right flank rib pain, stalking rib or abdominal distension, languid, limpness of the waist and knees etc. After treatment, compared with before treatment both groups were statistically significant difference (P<0.05); The curative effect of treatment group was better than control group, the difference was statistically significant (P<0.05).5. Safety evaluation:During the treatment, the patients of treatment group did not appear any adverse reactions,a patient of control group appeared mild diarrhea after taking the drug and exited the test.Conclusion The major pathogenesis of non-alcoholic steatohepatitis is Spleen eficiency and wet-sheng complicated with stasis and phlegm, the treatment of nourishing the spleen and dispelling dampness, resolving phlegm and accumulating blood can effectively improve the liver enzymology and clinical symptom of non-alcoholic steatohepatitis patients, the treatment has good clinical curative effect.The formulation based on this treatment is safe and effective for the non-alcoholic steatohepatitis patients.