| Rrenal failure (CRF) is the result of various kidney diseases, renal dysfunction, renal decompensation occur until a series of symptoms and a syndrome consisting of metabolic disorders is seriously endangering the life of the common people's health. The data indicate that at home and abroad this year, CRF incidence, prevalence rates increased significantly, the world is facing very serious situation, prevention and treatment, Chinese medicine in delaying progression of CRF, delayed onset of dialysis time and improve quality of life of patients with unique advantages, for domestic and foreign scholars have long affirmed. In this study, prospective cohort study to early and mid-patients with chronic renal failure study to Jiawei Shen Qi Di Huang Tang TCM-based health treatment programs based on Western Canada for the treatment of group therapy to Western medicine based treatment for the control group, by two years of follow-up observation, the main points from the clinical symptoms, degree of progress of chronic renal failure, end point, anemia, blood lipids and other biochemical markers to evaluate the delay in medical treatment of chronic renal failure in terms of efficacy.Subjects:1, the WM control group:from May 2008 to October 2010 in Peking University Third Hospital of renal out-patient treatment, consistent with chronic renal insufficiency (CRF) based on diagnostic criteria for receiving Western medicine therapy in patients with CRF were 57 cases 2. Chinese medicine treatment groups:from May 2008 to October 2010 than in the Xiyuan Hospital of Nephrology, director of outpatient Huan Ren, with complete medical records in line with Yin Deficiency Syndromes, taking western based therapy combined with Shen Qi Di Huang Decoction of CRF Patients 61 patients. Purpose:A prospective cohort study of patients with chronic renal failure as early as mid-term two-year long-term follow-up, through the detailed records of clinical symptoms and laboratory indicators, evaluation Shen Qi Di Huang Tang in the treatment of chronic renal failure in the role and efficacy.Methods:Because this study was a prospective cohort study, it is important to determine the consistency of the baseline. Collected before the first treatment in the treatment group and control group patient data integrity. Points from clinical medicine, serum creatinine, anemia, albumin, lipids and so there is no significant difference between the two groups, comparable. In the course of two years of detailed records of treatment of each patient's information. After two years in the observation from the following aspects were compared two groups of patients: Comparison of TCM syndrome score:efficacy rate by calculating the symptoms of patients in each group is divided into valid and effective, the establishment of four-character form, the chi-square test. (2) On the renal function of the comparison:by comparing the treatment for 12 months and 24 months (3) laboratory tests of statistical methods:detailed records of treatment for 12 months and 24 months of laboratory parameters, respectively, two groups of patients laboratory parameters before treatment and after treatment the difference between calculated, and two groups of 12 months and 24 months after the difference between groups t test, as if there were differences between the two groups were compared, thereby determining medicine the impact of treatment on laboratory parameters case. (4) The end point of the statistical methods:The chi-square test for independent samples to compare the existence of differences between the two groups to evaluate the impact of traditional Chinese medicine on the end of the event.Results:After two years of follow-up observation, research shows that:(1) compared with the control group, treatment group in improving renal anemia, correcting dyslipidemia, improving malnutrition was no significant difference. (2) monthly serum creatinine in patients with reciprocal (1/Scr) and time (month) to do scatter plots and found that Western medicine in the control group during 24 months of treatment, the overall downward trend in renal function, Chinese medicine treatment group,24 months of treatment, the overall process of the stable renal function, slow the recovery trend. The reciprocal of serum creatinine two groups of patients each month (1/Scr) and time (month) to do linear regression, and two t-slope b value Test showed statistical difference. After 24 months of treatment, Chinese medicine treatment group, positive b values (including b=0) 39 (68.42%), negative 18 cases (31.58%); Western values of the control group b positive in 24 patients (44.4%), negative 30 cases (55.6%). The tests showed a significant difference between the two groups. Show that the treatment group in the progress of renal damage, improving renal function better than the WM control group, significant differences exist between the two groups of. (3) 12 months after treatment, Chinese medicine treatment group, the effective integration of clinical symptoms in 38 cases (62.30%), ineffective in 23 cases (37.70%), compared with before treatment difference was statistically significant (P<0.05); Western valid control group,32 cases of clinical symptom score (56 14%), ineffective in 25 cases (43.84%), with significant differences before treatment (p<0.05). Showed no significant difference (p>0.05). Treatment of 24 months effective clinical symptom score Western 38 (66.67%), ineffective in 19 cases (33.33%). Chinese medicine effective in 51 cases (83.61%), ineffective in 10 cases (16.39%) exists between the two groups significantly different (p<0.05). (4) After 24 months of treatment, Chinese medicine treatment group had end point,6 cases accounted for 9.84%, Western control group had end point events in 9 cases, accounted for 15.79%, the two groups does not exist statistically significant. Conclus i ons:(1) Chinese medicine treatment group in improving renal anemia, regulate blood fat, improve malnutrition in the control group with no significant difference between Western medicine, but the two groups before treatment after treatment and there were significant improvements (P<0.05).(2) treatment group patients in the recovery of renal function, delaying the progress of renal damage in the control group was superior to Western medicine. (3) Traditional Chinese medicine treatment group in improving the clinical symptoms of patients with the control group than Western medicine. (4) TCM treatment group and control group in the western end of the event there were no significant differences, which may be shorter observation time and the relatively small number of cases related. If you increase the number of cases and observation time, can be more accurate conclusions. |
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