The Study Of Clinical Obserwation And Safety Of Shen Qi Di Huang Tang And Xiang Sha Liu Jun Zi Tang Used On Chronic Renal Failure

BackgroundWith the development of society, hypertension, diabetes increased gradually. And the incidence of chronic renal failure increased. Integrative therapy in the treatment of chronic renal failure is more and more important. Chinese medicine hospitals around the chronic renal failure Syndromes and make corresponding clinical development paths, and determine the basis medicine. How effective these herbs are? It needs the corresponding clinical data to support. The late disease, chronic renal failure without oliguria or urinary potassium excretion of abnormal, often leads to the occurrence of hyperkalemia. Traditional Chinese medicines as potassium, Decoction of potassium content can not be ignored. Would it lead to the occurrence of hyperkalemia when patients oraled chinese medicine for a long time? The corresponding experimental data needed to verify the safety of Chinese medicine.ObjectivesObervating the clinical efficacy of the decoctions of Shen Qi Di Huang Tang and Xiang Sha Liu Jun Zi Tang commonly used on chronic renal failure. Investigating the Safety of Shen Qi Di Huang Tang and Xiang Sha Liu Jun Zi Tang used on chronic renal failure from the point of serum potassiumMethodsClinical and experimental studies are used in the method of combining. A retrospective review of clinical research studies, collecting syndrome of "Spleen Qi Deficiency", "Qi and Yin Deficiency" in line with the conditions included chronic renal failure patients, oraled "Xiang Sha Liu Jun Zi Tang" and "Shen Qi Di Huang Tang, ". The same basic treatments are given to them all. Rating TCM symptoms and testing the serum creatinine before and two monthes after treatment to evaluate its efficacy. The determination of potassium content of decoctions:both Shen Qi Di Huang Tang and Xiangsha Liujunzi Tang decoctioned twice according to conventional methods of traditional Chinese medicine decoction and concentrated to 122ml. The potassium content of the decoctions will be analysised with flame method.Experimental research, the selected SD rats were treated with the classic 5/6 nephrectomy model of chronic renal failure glomerulosclerosis manufacture and maintenance of adenine administered to manufacture tubular necrosis in chronic renal failure model. Control group is set. One week after 5/6nephrectomy and one week after the administration of adenine, serum creatinine and blood urea nitrogen were tested to evaluate whether the models of chronic renal failure seted. And test potassium.Adenine adenine group was divided into model group, adenine Xiangsha conventional dose group, adenine Shenqi conventional dose group,2-fold dose Xiangsha adenine, adenine Shenqi 2 times the dose group.5/6 nephrectomy Group was divided into sham surgery, surgical Shenqi conventional dose group, surgery Xiangsha conventional dose group, dose 2 times Shenqi surgery, surgical Xiangsha dose 2 times. Chinese medicine was given to Chinese intervention group according Surface area. Control group, model group and sham surgery group were given the same dose of deionized water. Weighted them Regularly, and adjusted the quantity of administration. Blooded and tested the changes in blood potassium determination 4 weeks and 8 weeks later.Result38 patients were into Shen Qi Di Huang Tang study. Eight weeks after treatment, 4 cases were markedly effective,19 cases were effective,8 cases were stable, 7 cases were invalided. And total effective rate was 81.6%.45 cases were into Xiangsha Liujunzi Tang. And 8 cases were markedly effective,16 cases were effective,14 cases were stable,7 cases were invalided.Total effective rate was 84.4%.Determination of potassium content of two decoctions:Shen Qi Di Huang Tang conventional dose group:0.68g/dl; Shen Qi Di Huang Tang 2 times the dose: 1. 1g/dl; Xiangsha Liujunzi Tang conventional dose group:0.36g/dl; Xiangsha 6 Gentleman Tom 2 times dose:0.62g/dl.1 week after nephrectomy 5/6 and 1 week after the administration of adenine measured, blooded and tested serum creatinine and urea nitrogen, it was significantly higher than those in the control group. And the difference was significant (P<0.05).5/6 nephrectomy group serum potassium concentration was 6.21±0.60mg/l, serum potassium concentration of adenine fed group was 6.05±0.62mg/l, serum potassium concentration of the control group rats were5.80±0.62mg/l. And the difference was not significant (P> 0.05).4 weeks later, adenine model group, sham operation group and the dose groups in the intervention group compared with the control group, the difference was not significant (P> 0.05).8 weeks later, adenine model group, sham operation group and the dose groups in the intervention group compared with the control group, the difference was not significant (P> 0.05). The difference of the serum potassium concentration of Chinese intervention groups of 0 weeks,4 weeks, 8 weeks was not significant (P> 0.05).ConclusionShen Qi Di Huang Tang and Xiang Sha Liu Jun Zi Tang was effective used on the spleen and kidney qi deficiency syndrome of chronic renal failure patients. Both of Shen Qi Di Huang Tang and Xiang Sha Liu Jun Zi Tang used for a long time did not lead to hyperkalemia. And it was safety for clinic.