The Correlation Of Metabolic Syndrome And Bone Metabolism

Objective: To explore the association of metabolic syndrome and bone metabolismMethods: we collected the information of participants of healthy examination in our hospital who were dignosed as Metabolic syndrome according to the criteria of IDF and gathered the information of 166 cases as control group. They were all measured phalangeal bone mineral density with Ultrasonic Measurement produced by South Korea HUMAN TECHPIA. Osteocacin, bone alkaline phosphatase, parathyroid hormone were all measured with enzyme-linked immunosorbent assay. We used logistic regression models to assess the relationship between metabolic syndrome and bone metabolism.Results: Body mass index, waist circumference, waist-hip ratio, fasting blood glucose, blood pressure, triglycerides, cholesterol, low density lipoprotein in metabolic syndrome group was higher than normal control group (P<0.01), while high-density lipoprotein was lower (P<0.01). T values, Z values, osteocacin in metabolic syndrome group was lower than normal control group (P<0.05), while parathyroid hormone was higher (P<0.05), there was no significant difference of level of bone alkaline phosphatase between the two groups. T values in central obesity, high triglyceride, and hypertension group was lower than the normal group(P<0.05); Grouped by blood glucose, high density lipoprotein ,body mass index, T values in abnormal group and normal group were no significant difference. Height, weight, wist to hip ratio, systolic blood pressure, triglycerides were different among T1 group(T≥-1),T2 group (-2.5<T<-1) and T3 group (T≤-2.5) (P<0.05); Waist to hip ratio, systolic blood pressure, triglycerides in T3 group was higher than T1 group (P<0.05), while height, weight was lower. Factors that was negative correlation with bone mineral density T values include age (r=-0.167,p=0.000), gender (r=-0.101,p=0.001), waist to hip ratio (r=-0.0135,p=0.005), systolic blood pressure (r=-0.162, p=0.001), triglycerides (r=-0.142,p=0.003), metabolic syndrome (r=-0.118, p=0.014); Body mass index(r=0.248, p=0.000) was positive with T values . After adjustment for age and gender, the correlation still exists. Waist to hip ratio and triglycerides were independently positive factors of osteoporosis(P<0.05); Waist to hip ratio (B=13.995,OR=1.196E6,CI:362.277-3.950E6,P=0.001) had the greatest impact on osteoporosis, followed by triglyceride(sB=0.427,OR=1.532,CI:1.091-2.153,P=0.014); Body mass index was independently and inversely associated with osteoporosis (B=-0.194,OR=0.824,CI:0.696-0.975,P=0.024). After adjustment for age and sex, the association was also found. Metabolic syndrome was a risk factor of osteoporosis(B=0.857,OR=2.356 ,CI:1.184-4.687,P=0.015), but the relationship still set up after adjustment for age and sex.Conclusion: In metabolic syndrome group, Bone mineral density and osteocacin decreased, but parathyroid hormone levels increased comparing with the control group.The abnormal metabolic components were significantly associated with bone mineral density. Bone mineral density decreased in abnormal group of waist circumference, triglycerides and blood pressure. Waist to hip ratio, triglycerides and blood pressure increased, as T values reduced. Body mass index was an important protective factor of osteoporosis, Waist to hip ratio was an independent risk factor. Metabolic syndrome as the aggregate of multiple metabolic disorders was prone to osteoporosis.