The Clinical Study Of Metabolic Disorders And The Correlation With Adipocytokines In Pcos Women

Part IThe clinical study of metabolic disorders in PCOS women Objective: To explore the characteristic of metabolic disorders between adolescent and child-bearing period PCOS women with obesity or without obesity. Methods: 80 cases of PCOS patients were according to obesity divided into 52 patients with PCOS (BMI≥25kg/m2) and 28 patients with non-obese PCOS (BMI<25kg/m2), and according to age divided into 36 cases of adolescent (age 14-19 years) and 44 cases of child-bearing age PCOS patients (age 20-32 years). We collected the medical histories, measured height, weight, waist circumference, hip circumference, blood pressure, Ferriman-Gallway score for hirsutism, Rosenfield score for acne; The basis of sex hormones, oral glucose tolerance test(OGTT), insulin releasing test(IRT), serum lipid, liver function test were observed; the ultrasonography of pelvic and visceral were executed. Result: (1)Compared with non-obese PCOS women, the obese PCOS women had significantly higer fasting blood insulin, HOMA-IR; fasting blood glucose, AUCG; serum lipid (TC,TG,LDL,ApoB),and the more serious impaired glucose tolerance(IGT).(2)Compared with adolescent PCOS women, the child-bearing period PCOS women had significantly higer AUCG, serum lipid, and more serious impaired glucose tolerance(IGT). Conclusions: The adolescent and child-bearing period PCOS patients always have different degree metabolic disorders. The obese PCOS women especially obese child-bearing period PCOS women may have increased risk of suffering from metabolic disorders in glucose and lipid. For adolescent PCOS women particularly obese ones, we should take early screening, diagnosis, intervention, to avoid the further development and long-term complications.Part IIThe correlation of metabolic disorders with Adipocytokines in PCOS womenObjective: To study the relationship between serum Adipocytokines——FABP4, Visfatin ,RBP4 and metabolic disorders in women with PCOS.Methods: Eighty PCOS women and 42 control patients with tubal infertility or healthy volunteers were selected over the same time. According to BMI and age they were divided into 23 cases of adolescent obesity PCOS group (age<19 years old, BMI≥25kg/m2), 13 cases of adolescent non-obese pcos group (age<19 years old,BMI<25kg/m2), 29 cases of adult obese pcos group (age>19 years old, BMI≥25kg/m2), 15 cases of adult non-obese pcos group(age>19 years old, BMI<25kg/m2),13 cases of adolescent control group, 29 cases of adult control group. Serum Adipocytokines——FABP4, visfatin ,RBP4 levels of all the groups were detected by enzyme-linked immunosorbent assay (EL ISA) method. Results: (1)Serum FABP4 levels of obese PCOS groups were significantly higher than that of non-obese PCOS groups, which of non-obese PCOS groups were significantly higher than control groups, both adolescent and audlt PCOS groups had this difference. Correlation analysis showed that serum FABP4 levels were positively correlated with INS0h,2h, HOMA-IR, TG, TC, ApoB, LDL. (2)Serum Visfatin levels of obese PCOS groups were significantly higher than that of non-obese PCOS groups, both adolescent and audlt PCOS groups had this difference, which of non-obese PCOS groups were significantly higher than control groups and the difference only existed in the adolescent PCOS groups, but not in the audlt PCOS groups. Correlation analysis showed that serum Visfatin levels were positively correlated with INS0h,1h, HOMA-IR and negatively correlation with HDL. (3)Serum RBP4 levels of adult obese PCOS groups were significantly higher than that of control PCOS groups. Correlation analysis showed that serum RBP4 levels were positively correlated with TC.Conclusions: Adipocytokines had varying degrees of relevance with IR and lipid metabolism disorders, which were contributing to dysbolismus in PCOS women. Among these adipocytokines, FABP4 had the closest relationship with metabolic disorder in PCOS women including adolescence and adult patients; Visfatin seems to playing a greater role in the early stage of of metabolic disorder in adolescence PCOS women. In contrast, although RBP4 was associated with PCOS, but the relationship was slightly Sensitive.