| Objective:Osteoarthritis is the older of the common disease.Many scholars in recent years the disease has been studied and discussed.This study was to investigate the treatment of osteoporosis proprietary Xianlinggubao capsule treatment of osteoarthritis of the intervention, and to conduct clinical and Glucosamine capsules were to explore Xianlinggubao capsule on osteoarthritis of various clinical syndromes efficacy, development of new uses for the drug to provide the basis for the prevention and treatment of osteoarthritis provide new methods and drugs.Methods:The National Eleventh Five-Year project on "Control of the intervention of osteoarthritis," the preparatory work, based on 220 cases randomly selected patients with osteoarthritis group intervention, which Xianlinggubao group of 100 people, all 50 urban and rural areas; Puli group of 80 people, all 40 urban and rural areas; blank control group of 40 people, all 20 urban and rural areas,50% for each gender in each group.Xianlinggubao group received oral Xianlinggubao per person per Capsule 1.5g,3 times a day, continuing to take six months; medication medication surveys completed form, registration form adverse drug reactions, Drug release and other related forms recycling registration form to track drug use situation. Puli each group were given oral administration of Puli Hydrochloride per 0.24g,3 times a day, continuing to take three months; also fill in the same group with Xianlinggubao form. Control group not given any medication or placebo intervention, or fill out any forms. Return visit after a year, including the questionnaire and the second x-ray inspection.According to the information available to compare the clinical efficacy of both drugs. And analyze the relationship between the syndrome and the effect to examine Xianlinggubao capsule on the treatment of osteoarthritis. Results: 1 Xianlinggubao patients with bone and joint capsule on the impact of generalXianlinggubao patients group and Puli better overall mental health, physical activity more comfortable before taking the flexible, powerful voice, less smell, and moaning voice.Study malaise, weakness symptoms improved; joint paresthesia, numbness of limbs and other symptoms Bie expansion improved or disappeared; alpine attack, fatigue and other aggravating factors impact on the joints to reduce or disappear. Some and evidence such as insomnia, vertigo, tinnitus improved. Mental state of the control group were poor, generalized weakness, limb weakness, limited mobility, such as no better than a year ago, Zhuance sits up groaning heard the sound of aggravating factors exist and there was no impact on the joints to reduce. Two patients with osteoarthritis treated group was better than general control group. 2 Xianlinggubao bone and joint capsule on the main symptoms and signs of disease 2.1 The PainXianlinggubao group and Glucosamine pain patients have different degrees of improvement in symptoms, Xianlinggubao clinical control group of 50 cases,28 cases of significant progress, progress in 14 cases, no 0, total effective rate of 100%._Glucosamine clinical control group of 39 patients,20 cases of significant progress, progress in 12 cases, no3 cases, the total effective rate 93.42%._Compared with the control group there were significant differences (P<0.05); Xianlinggubao group compared with Chinese and there was significant difference (P<0.05). 2.2 Swelling Xianlinggubao group and Glucosamine groups swelling symptoms were improved, Xianlinggubao clinical control group of 47 patients,31 cases of significant progress, progress in 18 cases,1 patient, the total effective rate 98.97%. Glucosamine clinical control group of 13 cases,35 cases of significant,progressive in 21 cases, no 7 cases, total effective rate 90.79%. Xianlinggubao group swelling better than Glucosamine group were significantly different (P<0.05). 2.3 Morning stiffnessXianlinggubao group and the Portuguese established groups have different symptoms of morning stiffness improved Xianlinggubao clinical control group of 16 cases, no 32 cases of significant progress, progress in 40 cases,9 cases ineffective, the total efficiency of 90.72%. Glucosamine clinical control group of 8 cases,17 cases of significant progress, progress in 22 cases, ineffective in 29 cases, the total effective rate 61.84%. Compared with the control group there were significant differences (P<0.05); the two medication groups, morning stiffness Xianlinggubao the treatment group is better than Glucosamine group were significantly different (P<0.05). 2.4 The sound(feeling) of friction jointsXianlinggubao group and the group of joints with Glucosamine fricative (flu) was significantly reduced Xianlinggubao clinical control group of 18 cases,27 cases of significant progress, progress in 39 cases,13 cases ineffective, the total efficiency of 86.60%. Glucosamine clinical control group of 15 cases,38 cases of significant progress, progress in 19 cases, no 4 cases, total effective rate of 94.74%. Compared with the control group were significantly different (P<0.05); the two medication groups, the Portuguese established group on the joint friction sound (feel) the treatment is better than Xianlinggubao group, were significantly different (P<0.05). 3 Xianlinggubao capsule on patients Efficacy of different syndromesXianlinggubao clinical control group of liver and renal insufficiency in 13 cases control,23 cases markedly effective,2 cases less effective,0 cases none effective, spleen and kidney deficiency type clinical control 7 cases were cured,1 case markedly effective,4 cases less effective, and 3 cases none effective, liver Clinical control impotence deficiency syndrome in 8 cases control,19 cases were markedly effective,2 cases markedly effective,4 cases none effective. Puli clinical control group of liver and kidney insufficiency in 5 cases control,18 cases markedly effective,3 cases less effective,3 cases none effective, the clinical control of spleen and kidney deficiency type 1 case control,9 cases markedly effective,10 cases less effective,5 cases ineffective, liver and kidney deficiency Clinical control of type 4 cases control,9 cases markedly effective 3 cases less effective,6 cases ineffective.Insufficient liver and kidney, tendons and stasis type, spleen and kidney deficiency, wet note and liver and kidney deficiency type joints, phlegm cross resistance syndrome type 3 group, Xianlinggubao group were significantly better than Puli group There were significant differences (P<0.05).Xianlinggubao lack of capsule on liver and kidney, tendons and stasis in patients with the most obvious effect, better than the spleen and kidney deficiency, wet injection and liver and kidney deficiency type joints, phlegm cross resistance type, there was a significant difference (P< 0.05).Conclusion: 1 Xianlinggubao capsule on the clinical efficacy of osteoarthrosis is indeed, no adverse reactions, can be further popularized. 2 Xianlinggubao patients with bone and joint capsule of the joint pain, swelling, morning stiffness, bone friction sound so obvious clinical symptoms, can improve the quality of life of patients, ease suffering of patients. 3 Xianlinggubao capsules of different syndromes in patients with bone and joint effect of different degrees, especially for liver and kidney deficiencies, tendons and stasis were more significant effect. |
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