Experiment The Affects Of "pkc, Mmp-9 Of Lung Tissue" Of Asthma Rats On "ma Xing Xiong Ting Combination"

AbstractPartⅠ:Animal experiments:Objective:To observe the expression of Ma Xing Xiong Ting mixture of PKC and MMP-9 in bronchial asthma lung tissue and explore the Ma Xing Xiong Ting Continuous Mixture on airway inflammation in asthmatic rats and its mechanism study.Methods:SD 60 rats were randomly divided into control group, asthma group, the Ma Xing Xiong Ting mixture of low, medium and high dose group, dexamethasone group. In addition to the control group, the other five groups underwent asthma models, Ma Xing Xiong Ting mixture three groups were given different doses of the appropriate dose of liquid medicine orally, the model group were given normal saline and dexamethasone groups were given the same dose of dexamethasone intraperitoneal injection.Observing by immunohisto chemistry the expression of the PKC and MMP-9 in lung tissue of rats and the changes of lung tissue pathology by light microscopy.Results:Ma Xing Xiong Ting mixture may inhibit secretion of inflammatory cells by inhibitting the expression of PKC and MMP-9 in asthmatic rats, So as to achieve regulating Th1/Th2 cytokine balance to reduce airway inflammation and airway remodeling interventions and alleviate the asthma situation.PartⅡ:the theoretic discussion on "Ma Xing Xiong Ting combination"。PartⅢ:Summary.