Research On Triggering Reliability Of Magnetic-control Drug Release Micro-robot

In recent years, as the incidence of ulcerative enteritis,colon cancer and other gastrointestinal diseases are increasing year by year, the site—specific drug delivery technology (SSDDT) has become a focus areas of international pharmaceutical drugs. Releasing drugs to specific areas in alimentary Canal by non-cable-type micro-robot and studying absorption characteristics of drugs at different regions, which are very helpful for development of new drugs and improving the effectiveness of traditional medicines.Based on analyzing the functional requirements of micro drug release robot, a systemic solution was proposed. The functional characteristics and physiological parameters of the human digestive tract were analyzed. The passive walking micro-robot program's feasibility was demonstrated. The micro-robot's main structure and sealing system were designed reasonably. A reasonable drive mechanism was selected through the analysis of the various options. The force analysis of the compression springs was done. A location mode to achieve the positioning of the micro-robot in alimentary Canal by detecting spatial magnetic field parameters was proposed. A numerical calculation of magnetic charge model based on cylindrical permanent's magnet magnetic field was studied. The cylindrical permanent magnet inside micro-robot was equivalent to magnetic dipole. The magnetic orientation equation based on magnetic dipole model was established. The permanent-magnet positioning signal processing circuit was designed based on HMC1023 magnetoresistive sensors. The triggering means of the compression spring drive mechanism was studied. Two trigger ways were proposed based on magnetic reed switch fuse circuit and pure magnetic mechanism respectively.Stiffness test platform of drug drive compression spring was built and the relative accurate stiffness value was got. Conduction magnetic field of reed switch was analyzed qualitatively. The experiment for testing influence of the reed switch length of reed-pin and bending to its triggering magnetic field was done. The best on-field direction setting was proposed. A feedback signal circuits was designed in order to confirm whether the drugs is released. The circuit simulation software Multisim was applied to simulate a Hilary oscillator circuit. A small TV signal reception was used to test the signal of the flapper circuit. The result demonstrated that the signal transmission circuit is completely feasible. The drug release experiment of compression spring model with pure magnetic mechanism trigger was successful.