Study On The Characteristics Of Pathogenic Factors Of Chronic Gastritis And The Regularity Of Prescription Of Common Prescription

Objective:To explore the characteristics of the risk factors of chronic gastritis, aims to provide the basis for the prevention and treatment of chronic gastritis, and provide reference for TCM syndrome differentiation of chronic gastritis. To analyze composition principles of formulas treating distention and fullness from Prescriptions of Traditional Chinese Medicine Dictionary (PTCMD) provided reference basis for clinical treatment and new drug research of distention and fullness.Method:The first study was taking in patients with chronic gastritis as the research object. Through collecting multicenter cases, and investigating the epidemiological data with modern mathematical statistic methodology, the research arrived at the characteristics of the risk factors of chronic gastritis. The second study was searching the formulas treating distention and fullness from PTCMD which was stored in Traditional Chinese Medicine Inheritance Support System, normalized its name, and analyzed the composition principles of those formulas by using data digging methods including descriptive statistical analysis, association rules algorithm, complex system entropy clustering method.Results: ①The paroxysm of chronic gastritis is associated with age, in the majority with youth and middle-aged people. H. pylori is one of the most important pathogenic factors. Present and past infection of it is also the cause of chronic gastritis progression. Cigarettes, alcohol, power of work are the causes of chronic gastritis and influence factors of its progression. More than 50% patients had eating preferences, in which spicy, sweet and sour taste are the highest proportion. Disorders of dinner, preferences for piquancy, cold food and carbonated drinks are associated with the paroxysm of chronic gastritis. Preferences for spicy, acid, sweet, salty food, vegetarian, meat, smoked and salted food and hard dry food, eating fast are the influence factors for chronic non-atrophic gastritis running to chronic atrophic gastritis. Modern factor is one kind of the risk factors of chronic gastritis, gives priority to anger. Climate factor is one of the risk factors of chronic gastritis, giving priority to catching cold. Both are the important risk factors of its progression. Patients with history of gastrointestinal diseases, family history of chronic gastritis, family history of cancer are associated with the causes of chronic gastritis. Family history of cancer is the influence factors for chronic non-atrophic gastritis running to chronic atrophic gastritis.②Totally 270 Chinese medicine herbs were involved in the 248 prescriptions treating distention and fullness, and 27 herbs’frequency were over 10%.Through the analysis of association rules algorithm, the study gained 44,16 and 5 medicine pairs in the condition of 10%,15%,20% support degree and confident degree set as 0.6. Moreover,18,4 and 4 association rules between herbs were got. Via complex system entropy clustering,8 potential medicine pairs were got.Conclusion:Firstly, age, H. pylori infection, power of work, smoking, drinking, dietary factors and modern factors, climate factors, family history are the important pathogenic factors. They are also the influence factors for chronic non-atrophic gastritis running to chronic atrophic. Secondly the mainly used herbs for treating distention and fullness in the PTCMD were those tonifying the spleen and invigorating the stomach herbs, regulating qi and dispersing fullness herbs. In clinic, the site of distention and fullness was stomach, and related with spleen and liver. And the key pathogenesis was based on the spleen-stomach weakness and qi movement stagnation.