Effects Of Gradually Training On SOD,TNF-α Of NIDDM Rats

Object: Diabetes Mellitus is described as a metabolic disease, which has been becoming more common and harmful. Exercise therapy is an important aspect in combined therapy of Type 2 Diabetes Mellitus. This study investigated the effect of exercise therapy on the weight, glucemia, lipidemia, plasma insulin , free fat acid, TNF-α and SOD of diabetic rats. Methods: 28 from 58 male rats were randomized into quiet group for control(group A), exhausted once group(group B), trained group for control(group C). The others were fed with STZ and high dosage of lipid diet in order to produce diabetic rats model. The ideal model rats were randomized into quiet diabetic group(group D) and exercise diabetic group(group E). The diabetic rats were still given high dosage of lipid and the others normal diet. In the following 8 weeks the exercise of rats in trained group were strengthened gradually from 20 min per time in the first week to 90 min per time in the eighth week; that is 10 min always added into the training of the next week, and five times for every week. The hearts, livers and blood were taken for the measurement of related index when the training was ended in the eighth week. Results: ① TNF-α of the exhausting group and diabetes mellitus group increased significantly suggested excessive TNF-α might do harm to the body.② The SOD of exercising group increased more than the group for control with remarkable differences suggested exercise could strenthen the ability of anti-oxidation of the body. The Mn-SOD of the exercising diabetes mellitus group increased more than the quiet diabetes mellitus group suggested exercise could strenthen the ability of anti-oxidation of the diabetes mellitus rats mainly by Mn-SOD.