The Effect Of Low And Moderate Exercise On The Corticosterone, IL-2 And T-lymphocyte Subsets In Peripheral Blood Of SD Rats After Being Received Psychological Stress

Psycho-neuro-immunology( PNI )is a new science produced in 1970s, whose task is mainly describe the relationship between brain and body. The purpose is to understand then- relations from the level of molecule for relieving people' s disease. With the deep development of this research.more and more scholars begin to pay more attentions on the stress' research,for the reason that the body' s immune system can be influenced by the central nervous system and neurosecretory system during stress periods, which is usually 'harmful to one' s health. What kind of intervene measures could be used to antagonize the stress and keep the stability of one's immune system is becoming the top point in the PNI research.Traditional intervene measures often use congnition and medicine, however they can not be widely used for their high price and over-elaborated operation, also the right of operation often belongs to the few clinical doctors. If there has a convenient and effective intervene measures ,that could be a big breakthrough hi the PNI.As a suitable method for modern people , physical excise provide a new and scientific stand point in this field ,but why and what does it work? it is still not clear. In the experiment research .SDrats were divided into 7 groups ,one as control, one got the electrical footshock, and one received pure psychological stress only ,the other received forced swimming training for 6 weeks and psychological stress for 2 weeks in the later stage training, but the training last 30min and 60min separately. The IL-2 and corticosterone level and the number of T lymphocyte subsets in peripheral blood were measured. Result: Compared with the control group ,the IL-2 level of psychological stress was significantly lower than that of control; the number of CD3+ and CD4+/CD8+of psychological stress group had not significant change, but had the lower trend, while their corticosterone level was significantly higher than that of control.; the IL-2 and CD3+.CD4+/CD8+ levels of both 30min group and 60min group were significantly higher than that of control, while their corticosterone level was significantly lower than that of control; Compared with the stress group , the IL-2 and CD3+,CD4+/CD8+ levels of both 30min +stress group and 60min+stress group were significantly higher than that of stress group, while their corticosterone level was significantly lower than that of stress. Conclusion: The effect of exercise on psycho-neuro-immunology is likely related to the adaptation of HPA following chronic excise.