Study Of Cord Blood Adiponectin Concentrations And Correlation Factors In Mothers With Gestational Diabetes Mellitus

Objective:To investigate the concentrations and the influencing factor of cord blood adiponectin(APN) in mothers with gestational diabetes mellitus(GDM), to explore the influence of GDM to the fetal APN metabolism and to analyze the relevance between APN metabolism and the fetal growth.Methods:Twenty five women with GDM as an experimental group and twenty five healthy age-matched pregnant women as a control group were included.1. Maternal and cord blood serum APN, insulin(INS), CP(C-peptide) concentrations were measured by radioimmunoassay.2. Maternal and cord blood plasma glycosylated hemoglobin A1c(HbA1c) concentrations were measured by immunosuppressive competitive method.3. Maternal fasting blood glucose(FBG) and neonatal blood glucose were measured by glucose oxidase method.Results:1. Both cord and maternal APN concentrations were lower in GDM than that of control subjects(P<0.01, P<0.05, respectively).2. Compared with control subjects, both cord and maternal HbA1c concentrations were significantly higher in GDM(P<0.01), and maternal INS, CP, FBG and cord INS concentrations were higher in GDM(P<0.05), and neonatal blood glucose concentrations at two hours in postnatal were lower in GDM(P<0.05), accompanied with a higher CP concentrations but without statistical significance.3. Compared with maternal blood, serum APN concentrations were significantly higher in cord blood(P<0.01), and serum CP, plasma HbA1c concentrations were significantly lower in cord blood(P<0.01), accompanied with a lower INS concentrations but without statistical significance.4. Pearson correlation analysis showed that cord APN was significantly related with maternal and cord HbA1c(r= -0.394, -0.414; P<0.01, respectively); was unrelated with maternal APN, INS, CP, FBG, cord INS, CP, neonatal blood glucose and HOMA-IR(P > 0.05). In GDM, cord APN was related with neonatal PI (r=-0.400,P<0.05) , was unrelated with maternal age, pre-pregnancy BMI, antepartum BMI, gestational age and birth weigh(P>0.05). There was no correlation between cord APN and all clinical data in control subjects(P>0.05).Conclusions:1. Fetal adiponectin is mainly derived from fetal own tissues. It has a relatively independent regulation system in fetal APN metabolism, and don't be influenced directly by maternal APN concentration.2. The decrease of fetal APN in GDM has relevance with the fetal own glucose metabolism to some extent. It maybe predict the infant insulin resistance(IR) and the risk of future metabolic diseases in the offspring of GDM.3. APN involved in the fetal growth, the study of the changes of fetal APN concentrations in GDM can provide a reference and a new research direction about the early prevention of their offspring's long-term complication.