The Clinical Research On The Effect Of Qingre Xiefu Chinese Traditional Medicine In The Treatment Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease(AECOPD)

Objective: To observe the clinical effect of Qingre Xiefu Chinese traditional medicine in the treatment of AECOPD by analyzing the symptom signs,the date of blood gas analysis,pulmonary function test,Six minutes walking test of patients and study the mechanism of action.Methods: Ordering numbers according to the patients visiting time, forty two hospitalized AECOPD patients with retention of phlegm heat syndrome in the lung were divided into two groups randomly,the remedial group and the control group, each containing twenty-one patients. Patients in the control group were treated with routine method according to 2007 Guideline for Diagnosis and Management of COPD issued by Chinese Society for Respiratory Disease. In the remedial group, we added Qingre Xiefu Chinese traditional medicine in the treatment and let patients take it per day from the beginning of the experiment. The total course of treatment in each group was ten days. Comparing the clinical symptoms, the date of blood gas analyses, lung function test, six minutes walking test of the two groups before and after the treatment.Result: Clinical control and apparent rate of the remedial group was 23.8% and the control group 14.3% after treatment. There were no obvious differences between the remedial group and the control group (P>0.05).1 There was no obvious difference in clinical symptoms (cough, phlegm, pant e.g.) before treatment between the remedial group and the control group (P>0.05), which are comparable. The score was 23.76±3.46 before treatment and 9.86±4.09 after treatment in the remedial group. It was 23.86±3.07 and 13.43±4.07 before and after treatment in the control group. There was obviously differences between the remedial group and the control group after treatment (P<0.05). It was manifested that the curative effect in the remedial group was more notable than that of the latter.2 There was no major difference between the two group in the lung function before treatment (P>0.05). It was comparable. FEV1% was 56.42±3.84 before and 63.53±3.83 after treatment in the remedial group. It was 56.97±4.76 and 62.02±4.08 after treatment in the control group. There was no obviously changes between the remedial group and the control group after treatment (P>0.05). FEV1/ FVC was 59.60±3.36 before and 65.17±2.40 after treatment in the remedial group. It was 60.00±3.57 and 64.09±2.90 before and after treatment in the control group. There was no obviously changes between the remedial group and the control group after treatment (P>0.05). But there were greatly differences on FEV1% and FEV1/ FVC in the remedial group after treatment (P<0.01).3 No obvious difference was observed in the blood gas analyses of the two groups before treatment(P>0.05). It was comparable. PaO2 in the remedial group was 73.90±11.54 and 92.95±4.67 before and after treatment. It was 74.19±11.22 before and 91.29±5.02 after treatment in the control group. PaCO2 was 46.33±4.34 and 41.76±2.10 before and after treatment in the remedial group. It was 47.10±3.60 before and 42.76±2.39 after treatment in the control group. There was no obviously changes between the remedial group and the control group after treatment (P>0.05). But there were greatly differences on PaO2 and PaCO2 in remedial group after treatment (P<0.01).4 Six minutes walking test of the two group had no obvious difference before treatment (P>0.05). It was comparable. It was 444.52±39.90 before treatment and 471.24±37.63 after treatment in the remedial group. It was 442.57±40.53 before treatment and 468.52±38.36 after treatment in the control group. There was no obviously improvement in pulmonary function between the two groups after treatment (P<0.05). But there were greatly improvment on Six minutes walking test in remedial group after treatment(P<0.01).Conclusion:Qingre Xiefu Chinese traditional medicine was instructive to the AECOPD patients with retention of phlegm heat syndrome in the lung. It is effective in dispelling away heat-evil and resolving phlegm, the clinical symptoms of which were ameliorative, with organism immunity improved.