Clinical Analysis On The 41 Cases Of Primary Fallopian Tube Carcinoma

Objective:To explore the factors affecting the diagnosis,therapy and prognosis of the primary fallopian tube cancer.Methods : SPSS 13.0 software package was used. Theχ2-test,Kaplan-Meier survive curve are applied to retrospectively evaluating the 41 patients who had been diagnosed with primary fallopian tube carcinoma in the Fouth Hospital of Heibei Medical University.Results:1 From January 2003 to December 2009 , the incidence rate of primary fallopian tube carcinoma was 1.1% of gynecological malignant tumors in the Fouth Hospital of Heibei Medical University.2 The 1-year,3-year overall survival rates after surgery were 94.6%,71.4%,and the death-associated 7(17.1%).3 The median age was 58 years,73.2% of primary fallopian tube carcinomas were post-menopause women.4 Vaginal bleeding or discharge and palpable pelvic mass are the most common symptoms and signs in primary fallopian tube carcinomas.5 Pathology: the tubal adenocarcinoma account for 85.4%,and unilateral disease 80.5%.6 After surgery or chemotherapy , tumor metastasis or recurrence associated with a significant increase of CA125.7 The preoperative diagnosis rate is 12.2%.8 The basic type of surgery was total hysterectomy,bilateral salpingo oophorectomy and omentectomy, and (or) lymphadenectomy.9 The 3-year survival rates was 100% in patients with early stage disease (stages I, II) and was 45.5% for patients with stages III and IV (P<0.05).20 patients less than 58 years and 21 greater than or equal to, the 3-year survival rates was 66.7% in the former and 57.1% in the latter(P>0.05). The 3-year survival rates was 72.7% in patients with unilateral tubal disease and was 40.0% for patients with Bilateral tubal disease(P>0.05).The 3-year survival rates was 100% in patients with pelvic lympha- denectomy, 83.3% for patients with pelvic and para-aortic lympha- denectomyand and 59.5% for patients with non-lymphadenectomy(P>0.05).The 3-year survival rates was 88.9% in stages III patients with lympha- denectomy and was 19.0% for stages III patients with non-lymphadenectomy (P<0.05).The 3-year survival rates was 75.0% in patients with TP combination chemotherapy and was 58.3% for patients with PC combination chemotherapy (P>0.05).Conclusion:1 The preoperation diagnosis rate is 12.2%. The color Doppler ultrasound and laparoscopy check may contribute to the diagnosis of primary fallopian tube carcinoma when climacteric women with pelvic mass, irregular vaginal bleeding ,fractional curettage and high CA125 levels.2 CA125 is an important indicator monitoring the development and prognosis of primary fallopian tube carcinoma.3 Clinical stage was the most important prognostic factor in the overall survival.4 The systematic pelvic and abdominal para-aortic lymphadenectomy can stage accurately, guide adjuvant therapy, and also improve the prognosis markedly.5 Age, tumor location and chemotherapy maybe the factors affecting the prognosis.