Study Relationship Between TCM Syndrome Elements Of Hypertension And Hemotheology Indexes

Objective:Observing hypertension patients' hemotheology indexes(whole blood viscosity of high[200/S]shear stress,whole blood viscosity of middle[50/S]shear stress and whole blood viscosity of low([5/S] and [1/S])shear stress,whole bloo d reduced viscosity of high shear stress,whole blood reduced viscosity of low s hear stress,whole blood relative viscosity of high shear stress,whole blood relati ve viscosity of low shear stress,plasma viscosity,hematocrit(HCT),erythrocyte sed imentation rate (ESR),K,red cell stiffness index,red cell conglomeration index,re d cell deformability index,fibrinogen(FIB))in order to find out the relationship b etween hemotheology indexes and syndrome elements(Qi deficiency,Yin deficien cy,Yang hyperactivity,phlegm and dampness,blood stasis) of hypertension patient s.Methods:Collect 99 patients according with the Western medicine diagnosis st andard of hypertension Clinically and then separate them into different groups t hrough Bianzheng,and all the indexes of those mentioned above will be tested. Devide patients into single syndrome element group,two syndrome elements gro up,three syndrome elements group and four syndrome elements group by the n umber of their syndrome elements,then devide them into different groups by th eir syndrome element constitution.Classify them by the deficiency and excess s yndrome element of them,and by whether they have the blood stasis syndrome element or not.Finally compare the hemotheology indexes among the different groups,and study the distribution of syndrome element by the method of frequ ency distribution.Use t-test to compare sample mean between two qroups.All of the results will be checked up by statistics,then study the relationship between hemotheology indexes and TCM syndrome elements.Results:1 The comparison of population distribution of hypertension syndrome elements:r esults according to the quantity:two syndrome elements>single syndrome elemen t>three syndrome elements>four syndrome elements;results according to the typ es:the group of single syndrome element:Yang hyperactivity=phlegm and dampn ess>Yin deficiency>Qi deficiency>blood stasis,the group of two syndrome eleme nts:Yin deficiency+Yang hyperactivity=Qi deficiency+Yin deficiency>Yang hyper activity+phlegm and dampness>phlegm and dampness+blood stasis>Qi deficienc y+blood stasis>Yin deficiency+phlegm and dampness>Qi deficiency+phlegm and dampness=Yin deficiency+blood stasis=Yang hyperactivity+blood stasis,the grou p of three syndrome elements:Qi deficiency+Yin deficiency+phlegm and dampn ess>Qi deficiency+Yang hyperactivity+phlegm and dampness=Qi deficiency+phle gm and dampness+blood stasis>Yin deficiency+Yang hyperactivity+phlegm and dampness=Qi deficiency+Yin deficiency+blood stasis.2The conclusion of comparison of the hemotheology indexes of deficiency and excess syndrome elements groups is:in the group of single syndrome element,t he result of those indexes(whole blood viscosity,whole blood reduced viscosity of high shear stress,whole blood relative viscosity and HCT) is:excess>deficien cy(P<0.05);in the group of two syndrome elements:whole blood viscosity of mi ddle[50/S]shear stress:excess>deficiency and excess(P<0.05),whole blood viscosit y of low[5/S] shear stress:excess>deficiency,excess>deficiency and excess(P<0.0 5),whole blood viscosity of low[1/S] shear stress:excess>deficiency,whole blood reduced viscosity of low shear stress:excess>deficiency(P<0.05),red cell conglom eration index:excess>deficiency(P<0.05).On the whole,the total result can be su mmarized to be excess>deficiency and excess>deficiency.3The comparison result of the hemotheology indexes of syndrome elements(Qi deficiency,Yin deficiency,Yang hyperactivity,phlegm and dampness):the results of the whole blood viscosity,whole blood reduced viscosity of high shear stress,w hole blood relative viscosity of high shear stress and hematocrit(HCT) of Yang hyperactivity and phlegm and dampness are higher than those of Qi deficienc y and Yin deficiency(P<0.05),but there is no obvious difference between Yang hyperactivity and phlegm and dampness(P>0.05),so is Qi deficiency and Yin d-eficiency(P>0.05).4The comparison results of the hemotheology indexes of hypertension syndrome element and the corresponding conbination:the results of the deficiency syndro me elements and the corresponding conbination:whole blood viscosity of high[2 00/S] shear stress:Qi deficiency+Yin deficiency>Qi deficiency(P<0.05),whole blo od reduced viscosity of high shear stress:Qi deficiency+Yin deficiency>Qi defic iency(P<0.05),whole blood relative viscosity of high shear stress:Qi deficiency+ Yin deficiency>Qi deficiency(P<0.05),red cell stiffness index:Qi deficiency+Yin deficiency>Qi deficiency(P<0.05).There is no obvious difference between the ex cess syndrome elements and the corresponding conbination(P>0.05).The results of the deficiency syndrome element,the excess syndrome element and the corre sponding conbination are:whole blood viscosity:Yang hyperactivity>Yin deficienc y,phlegm and dampness>Yin deficiency,phlegm and dampness>Qi deficiency(P<0. 05),and whole blood viscosity of high[200/S]shear stress:Qi deficiency+phlegm and dampness>Qi deficiency(P<0.05),whole blood relative viscosity of high shea r stress:phlegm and dampness>Qi deficiency+phlegm and dampness.Although th e rest of the results are according with the conclusion that excess>deficiency a nd excess>deficiency,P is higher than 0.05 by statistics.5There is no obvious difference between hemotheology indexes of the hyperten sion patients who have the blood stasis syndrome element and those who don't have(P>0.05).Conclusions:lAt the present time hypertension results from the mutual effect of two syndro me elements. Of course,the roles they play in the lesion aren't the same,but ther e is also single syndrome element that leads to the disease.More than two path ological factors often come into existence at the later stage of the disease and make the disease more complicated.Hypertension often results from the action of Yin deficiency and Yang hyperactivity,and pathological products such as phl egm-dampness and blood stasis often come into existence in the progress of th e disease.Qi and Yin deficiency often come into existence at the end of the di sease.There are often hlegm-dampness and blood stasis for those people who ar e in the late stage of the disease and their disease is often more complicated. 2The level of the hemotheology indexes of the hypertension patients commonll y is excess>deficiency and excess>deficiency.The excess syndrome patients' vita 1 Qi isn't deficient,so their hemotheology indexes are higher.The deficiency syn drome patients'vital Qi is deficient,so their hemotheology indexes are not so h igh.That means the increase of blood viscosity leads to the decrease of tissue perfusion,because the excess syndrome patients' vital Qi isn't deficient,so they c an insease the blood pressure to preserve normal perfusion but also increase th e blood viscosity.The deficiency syndrome patients' vital Qi is deficient,so their blood viscosity is not increased as much as the excess syndrome.The excess a nd deficiency syndrome element often change with the hemotheology indexes.3The rise of the hemotheology indexes of hypertension is often related to the Yang hyperactivity and phlegm and dampness,the hemotheology indexes of thos e people who belong to the Qi deficiency and Yin deficiency don't rise as hig h as those of Yang hyperactivity and phlegm and dampness.4When different syndrome elements act upon one another,their hemotheology in dexes changes but not adding together simplly.5The increase of the hemotheology indexes is not only exist in the blood stasi s syndrome.It also means blood stasis is one of the potential etiology of hyper tension.6The increase of the blood viscosity is an important link in the happening and progress of hypertension.It changes following the disorder of the blood pressur e,neuroregulation,blood sugar,blood fat,electrolyte,hormone.According to this stud y,we know that blood viscosity also changes following the syndrome element. The increase of blood viscosity of hypertension is the maladjustment of system, tissue,organ,nerve and body fluid,also the maladjustment of ZangFu QiXue and YinYang.It is a link of the pathological change, so if we decrease the blood viscosity,not only can we treat and block up the progress of hypertension,but a lso prevent the happening of hypertension complication to a certain extent.