Qi Spirit Decoction "in The Treatment Of Renal Bone Malnutrition Rats Mechanism He Experimental Research"

Objective: to observe Qi spirit of renal bone soup nutrition research in rats, the mechanism of kidney, Ca, P metabolism, blood and bone metabolism of PTHeffects. To clarify Qi spirit decoction "in the treatment of renal bone malnutrition rats mechanism.Methods: this topic Wistar rats with males, 60, raised after 1 week 6 groups were randomly divided into 10, take back sides, after exposure to the kidney, incision, as normal control group, suturing the rats also may/June nephrectomy nephrectomies, right (left kidney remaining 1/3), high phosphorus diet, cause of chronic renal failure animal model. After the successful, the treatment group and control group Qi spirit by renal bone soup, Jane helle treatment. Article 12 the retention samples after the weekend blood calcium, phosphorus ion test, urea nitrogen, serum creatinine, remove surplus kidney with 10% formalin fixed specimens of ria usingsolution method,OPG,BGP,BMP-7.With automatic biochemistry analyzer, P, Bun measuring Ca respectively.Results: the model of success. Preparation, Through the treatment group inQispirit soup in OPG BGP, BMP-7,calcium, phosphorus, etcbetter treatment model group, P<0.01, compared with positive group(P<0.05).With Jia Shou Shu reagent blank group (P>0.05) analysis,no statistical significance.Conclusion: 1.Qi spirit soup can obviously improve the nonglomerular morphometry rats, and kidney pathological damage effect is better than positive control. The mechanism for Qi spirit through promoting bone soup OPG and BMP-7 osteoclast proliferation and differentiation, bone resorption function abate, to improve symptoms.2.Qi soup and positive spirit, can increase the content of bone OPG.3.Qi spirit soup can improve renal pathology sex morphometry, compared with model can improve renal group within the masculine expression BMP-7.