The Clinical Research Of Curative Effect Of Change Of Levels Of Serum Leptin And CRP TongBi Grains On Patients Of Coronary Heat Disease (CHD) Suffering From Angina Pectoris (AP) Combining Metabolic Syndrome (MS)

【Objective】This study was to research and observe the clinical curative effect of TongBi grains, level's change of blood fat,serum Leptin and CRP on patients of CHD suffering from AP combining MS(the stomach type fat) after taking medicine of TongBi grains.Explain whole squareses to play the tonifying spleen to turn totally go spirit to dispel phlegm to pursue stasis, go to the effect of opening Yang,spreading knot and going obstruction from theory of Traditional Chinese medicine. This study elaborate that the square improves the insulin resist(IR) from angle to the doctor, beating off cardiovascular dangerous factors completely, prevention and curing patients of CHD suffering from AP combining MS in mathod of many linkses and targets, furthermore inquiry into its function mechanism.【Methods】This topic adopt method of the theories studies to combine together with the clinic observation,the theories researching lays foundation, the practicing examination verify clinical result.The theories research mainly set out from the relation to qi stagnation blood stasis, phlegm muddy,MS and CHD, inquiry into output mechanism of CHD suffering from AP combining MS. The experiment adopt the method of random and check against, observed 60 CHD suffering from AP combining MS (the stomach type fat) sufferer.The method is that the 60 divided into two sets on random, give each set respectively the normal regulations western medicine treatment and the foundation of normal regulations western medicine add to take tongbi grain treatment.The period of treatment is 4 weeks,do electrocardiogram(ECG) in front and back of the treatment, laboratory testing blood fat , Leptin and CRP. the chemical examination of serum Leptin use emanation immunity method.The laboratory testing of serum CRP use the immunity method of association.【Results】1. After curing, Two sets of sufferers curative effect of the Chinese medicine and the AP curative effect certificate better than treatment front; Set comparison show that CH group set better than control group, Have obvious difference(P<0.05).2.Two sets of ECG behind of curing the compare the treatment all had an improvement ago, set relatively do not show obvious difference(P>0.05).Two sets of stop to reduce the rate comparison in the nitric acid glycerin up Have the obvious difference (P<0.05), curative effect of CH group set better than control group. 4.Two sets of sufferers level of blood fat , Leptin and CRP after curing to lower obviously. relatively having already shown the obvious difference before treatment(P<0.05); Set the comparison manifestation treatment set better than matched control, have the obvious difference of show.(P<0.05)【Conclusion】Tongbi grains have good curative effect on patients of CHD suffering from AP combining MS (the stomach type fat),and didn't take place poisonous side effect.Its function mechanism may is through improving the insulin resist,lowering level of serum Leptin and CRP,and lower the blood fat,blood pressure,blood sugar and the blood high stasis etc., Stabilize or converse the artery gruel kind hardens spot piece, improve coronary artery blood suppling, thus prevent and cure the coronary angina pectoris.【innovation】The creative of this topic be placed in an analysis pathologic mechanism the of CHD suffering from AP combining MS (the stomach type fat) from two angles of the Chinese medicine and doctor, make Chinese medicine and doctor is coming up to an organic combine in the prevention and cure of CHD . Pathologic mechanism: Born gift shortage with the day after tomorrow harm----The heredity and environment factor; dysfunction of spleen in transportation ----The insulin resist;qi stagnation,phlegm muddy and blood stasis knot with each other --The high blood pressure,high stasis appearance, high fat blood disease,the high insulin blood disease and high blood sugar etc. the gathering of the high dangerous factors.The chest sun flap--Coronary. Chest obstruction-Angina pectoris. different roads lead to the same goal. Prevention and cure:The tonifying spleen goes spirit to dispel (eliminate) phlegm to resolving stasis (the dialectical theory cure, specimen and cure)-Improve the insulin resist(IR), (whole idea) break up completely cardiovascular dangerous factors.the sun spread knot to Tong Bi to relieve pain--the anti- stasis adjust a fat to suppress inflamation to expand a hat, Different in approach but equally good.