| Objective: To explore and confirm the clinical efficacy and safety of Tongbi Decoction in the treatment of stable angina pectoris in elderly patients with coronary heart disease by using Tongbi Decoction.By comparing the degree of relief of symptoms,changes of electrocardiogram,blood lipid and other risk factors before and after treatment,and changes of ferritin before and after treatment,the effectiveness of Tongbi Decoction in the treatment of stable angina pectoris in elderly patients with coronary heart disease and its effect on ferritin level were discussed,which provided new directions and ideas for further research and treatment.Methods: 72 patients with coronary heart disease who met the inclusion criteria were divided into control group and treatment group according to random number table method.There was no significant difference in age,sex and course of disease between the two groups.Finally,65 patients were enrolled,32 in the control group and 33 in the treatment group.The control group was treated with routine western medicine,while the treatment group was treated with Tongbi Decoction on the basis of routine western medicine,one dose a day for 14 days.Clinical observation indexes were recorded before and after treatment,and the curative effect was judged by statistical method.Results:(1)The marked effective rate of the control group was 3.13%,the total effective rate was 28.13%,the marked effective rate of the treatment group was12.12%,and the total effective rate was 81.82%.The curative effect of the treatment group was obviously better than that of the control group.(2)Both the treatment group and the control group could improve the total score of TCM syndromes(P <0.01),but the treatment group was better than the control group in improving the total score of TCM syndromes(P < 0.01).(3)The control group had significant improvement in chest tightness or pain(P < 0.01),significant improvement in shortness of breath and fatigue(P < 0.05),no significant difference in dry mouth,spontaneous sweating,five-heart upset fever,insomnia and multiple dreams(P >0.05);the treatment group could effectively improve the symptoms of chest tightness or pain,shortness of breath,dry mouth,spontaneous sweating,five-heart upset fever and insomnia and multiple dreams(P < 0.01).There was no significant difference in improving chest tightness or pain,shortness of breath and fatigue between the two groups(P > 0.05);there was significant difference in improving dry mouth,spontaneous sweating,insomnia and multiple dreams(P < 0.05),suggesting that the effect of the treatment group on improving the above three symptoms was better than that of the control group;there was significant difference in improving five-upset fever(P < 0.01),suggesting that the treatment group had the effect of improving five-upset fever(P < 0.01).It is better than the control group.(4)Thecurative effect of electrocardiogram in the two groups was compared,P < 0.05,which showed that the treatment group was better than the control group in improving patients' electrocardiogram.(5)Comparing the efficacy of nitroglycerin cessation between the two groups,PC < 0.01 shows that the effective rate of nitroglycerin cessation in the treatment group is significantly better than that in the control group.(6)Ferritin in the treatment group before and after treatment was compared,P <0.01,the difference was statistically significant,suggesting that the treatment group had a significant improvement on the ferritin index.Ferritin in the control group before and after treatment was compared,P < 0.05,with statistical significance,suggesting that the control group drugs have an improvement effect on ferritin.The difference of ferritin between the two groups before and after treatment was statistically significant(P < 0.05),indicating that the treatment group could improve the ferritin index better than the control group.(7)There were no adverse reactions in the two groups before and after treatment.Conclusion: Tongbi Decoction is effective and safe in treating senile coronary heart disease(deficiency of both Qi and Yin with blood stasis).It can effectively reduce serum ferritin and blood lipid levels,especially in improving the symptoms of chest tightness or pain,shortness of breath,dry mouth,spontaneous sweating,five-heart upset and fever,insomnia and multiple dreams.It can improve the effective rate of clinical treatment and has a higher clinical use value. |
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