| [Objective]Through the clinical observation, carries on the Chinese medicine symptom analysis to diabetes partner depression patient, the choice has the liver strongly fragrant spleen weakness symptom characteristic diabetes partner depression patient,carries on the treatment with sparse liver Xie Yufa, and with only uses the western medicine to fall the sugar treatment the blank group comparison, then discusses sparse liver Xie Yufa to 2 diabetes merge depression patient insulin resistance influence.[Information]Conforms to "2 diabetes" to in the Hubei Province Chinese medicine hospital 2007-2009 year admitting outpatient service and in hospital patient and "the depression",the card is the liver strongly fragrant spleen weakness patient altogether 62 examples to conduct the clinical research.Selected information requirements1.Diabetes diagnostic criteria adopted Chinese Medical Associatin Diabetes Associatin in 1999 adopted by the "new diabetes diagnosis and classification" standard:Namely conforms to the empty stomach blood sugar(FPG)>7.0mmol/L or meal the latter 2 hours blood sugars(2HPG)>11.1mmol/L. "Drinks,the multi-food, the polyuria,the body weight drops" the symptom unclear notables to have to diagnose in another day determination.2.The depression diagnosis standard refers to "China Mental Nosology And Diagnosis Standard" (third edition).Diabetes despondent barrier diagnosis refers to a Chinese dense despondent meter (HAMD)24>20 minute.3.The Chinese medicine card waits to see the doctor breaks the standard any disease with thirst and excessive urination diagnosis standard to refer to "Chinese native medicine New Medicine Clinical Research Guiding principle". Yu Bing diagnoses the standard to refer to "Chinese medicine Illness Diagnosis Curative effect Standard".The liver strongly fragrant spleen weakness card diagnosis standard refers to "Chinese native medicine New Medicine Clinical Research Guiding principle",main card:The spirit is despondent,the tired asthenia,loses sleep; Inferior card:wan the abdomen abdominal bloating,the chest stuffy heaves a sigh happy, the constipation, accepts the difference; Tongue pale or fat, liver moss thin Bai Huoni,the arteries string slides or fragile incapable.Has above host card 3 items,the inferior card 2 items, conform to the tongue arteries performance to be possible to diagnose for the liver strongly fragrant spleen weakness card.4. Age scope in 18-70 year old.5.Before the treatment in a week does not have uses other anti-despondent medicinal preparation, in 2 weeks has not used the monoaminoxidase preparation, in the course of treatment the merge has not used other anti-despondent medicinal preparation and the anti-neurosis medicine.6. Course of an illness above December, before treatment in 2 weeks blood sugar basic stability, HBA1C≥6.9% also≤11.5%, empty stomach blood sugar<11mmol/L.7. Is willing to accept the clinical test also forecast compliance good.8.Chinese dense despondent meter (HAMD)24>20 minute, also≤35 minute.[Method]The choice simultaneously conforms to diabetes and diabetes despondent barrier diagnosis standard; Chinese medicine dialectical for liver strongly fragrant spleen weakness 62 examples, divides into the Chinese native medicine group, the blank group stochastically, completely receives the trying maintenance original diabetes foundation and falls the sugar medicine treatment to be invariable. Chinese native medicine group:Takes adds the taste Dan zhi ramble to disperse the decoction,200ml bid; Blank group:Only maintains the original diabetes foundation and falls the sugar medicine treatment.The treatment course is 12 weeks.The observation target is:HAMD meter,empty stomach blood sugar (FBG), after meal 2h blood sugar (2hPG),glycosylation hemoglobin (HBA1C), empty stomach insulin (FINS),cortisol (F)8Am, body weight index, insulin sensitive index (ISI).[Results]1.Around treatment HAMD meter integral comparison:After the treatment before the blank group meter total integral and the treatment compares not obvious difference P>0.05,non-statistics significance; Before the Chinese native medicine group treats the HAMD meter integral to treat reduces P< 0.01,treats after the blank group compares has statistics significance P<0.01.2.Around treatment FBG,2hPG, HBA1C comparison:After the treatment blank group this three items elevate, in which FBG (P< 0.01),2hPG (P<0.05),has the remarkable difference; After the treatment the Chinese native medicine group three items reduce P< 0.01,compares after the blank group, the Chinese native medicine group three items obviously drop FBG,2hPG (P< 0.01),HBA1C (P< 0.05).3.Around treatment empty stomach insulin, body weight index, insulin sensitive index comparison:After the Chinese native medicine group treats the empty stomach insulin to drop obvious P< 0.05,has the remarkable difference, ISI obviously rises P< 0.01, has statistics significance, the body weight index has the drop, but not obvious difference, non-statistics significance; Treats after the blank group compares the empty stomach insulin to drop obvious P<0.05,has the remarkable difference, ISI obviously rises P<0.05,has statistics significance.4.Around after the treatment the blood cortisol (empty stomach 8Am) compares the treatment the blank group to compare:After the blank group treats the blood cortisol ascension, after the Chinese native medicine group treats the blood cortisol remarkable drop, has statistics significance P< 0.01.[Conclusion]The Dan zhi ramble disperses adds the taste only then obviously to improve 2 diabetes partner depression patient's despondent condition, like the spirit is despondent,the tired asthenia,loses sleep accepts the inferior body symptom to be able to improve obviously, increased the compliance after the patient mood improvement which the patient treats,then might reduce the insulin resistance which the negative mood caused, thus was beneficial in the blood sugar control,moreover, the blood sugar control good might reduce or eliminate patient's negative mood, thus improved patient's quality of life, studied the data result to demonstrate the empty stomach insulin level dropped, the body weight index drops, the HAMD meter integral reduced,the blood sugar level could improve obviously,insulin sensitive index ascension, obviouslyThe insulin resistance reduced.May say applies sparse liver Xie Yu the method of treatment not to lose for improves 2 diabetes partner depression insulin resistance one effective method of treatment.
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