| [Objective]Through clinical observation, diabetes and depression were given to TCM Syndrome type, select the Liver depression in patients with spleen deficiency to be treated Danzhi Xiaoyaosan flavored side, and with pure hypoglycemic treatment group as control, emotional factors led him to study medicine with depression and diabetes by blood glucose relationships.[Clinical Data]Chinese medicine hospital admissions for 2007-2009 in Hubei Province, while consistent with diabetes and depression, liver depression cards are a total of 62 cases of patients with spleen deficiency retrospective clinical study.Selected information requirements:1. Diagnostic criteria for diabetes using WHO (1999) published diagnostic criteria for diabetes:the fasting plasma glucose≥126mg/d1 (7. Ommol/1) or 2h postprandial blood glucose≥200mg/d1 (11.1mmol/1) or diabetes symptoms (more drink, polyuria, polyphagia, weight loss)+at any time of plasma glucose levels≥200mg/d1(11.1mmol/1), the symptoms was not obvious who should be the other day to detect the diagnosis. 2. Depression diagnostic criteria:the light of "Chinese Classification and Diagnostic Criteria of Mental Disorders 3rd edition" (CCMD-3) standard Hamilton Depression Rating Scale (HAMD) (schedule see below) 24 total score>20points, and≤35points were.3. TCM diagnostic criteria:Diabetes diagnostic standard reference to "Chinese Medicine Clinical Research Drug Guidelines. " Yu diagnosis criterion-referenced, "TCM Syndrome Diagnostic efficacy standards." Liver depression and Spleen deficiency diagnostic criteria refer to "Chinese Medicine Clinical Research Drug guiding principles. " Main symptoms:mental depression, fatigue fatigue, fewer sleep soundly; views Disease:Zhongwan bloating nausea, chest tightness Xi Tai Xi, constipation, anorexia; tongue pale, or fat, thin white or greasy fur; pulse string slip, slim and fragile or weak pulse. Has three main symptoms above, sub-syndrome 2, in line with the tongue and Liver depression and spleen deficiency, pulse, can be diagnosed.4. Aged 18 to 60-year-old range are willing to accept clinical trials and predict compliance is better.5. Course of the disease more than 6 months, HbA1c≥6.9%, <11.5%, FPG<11mmol/L.6. Within 2 week before treatment is not the use of other antidepressants, treatment is not combined with other antidepressants, and antipsychotics.[Method]62 cases of type 2 diabetes patients with depressive symptoms were randomly divided into test group and control group,31 cases in each group, both groups with conventional diabetes treatment, On this basis, the test group focused on the treatment given to Danzhi Xiaoyaosan Modified.12-week course of treatment, observation indicators:HAMD scale, blood glucose, HbA1c, TCM points.[Results]1. Points before and after treatment HAMD scale comparison:the control group after treatment Scale total score compared with those before treatment was no significant difference (P>0.05). The test group after treatment points lower than that before treatment (P <0.01), compared with the control group after treatment was significantly (P<0.01).2. Before and after treatment FPG,2hPG, HbAlc of comparison: the test group after treatment FPG,2hPG, HbAlc 3 were significantly decreased (P<0.01); control group, FPG,2hPG, compared with before treatment decreased (P<0.01, P<0.05), HbAlc before and after treatment no significant changes. After treatment compared with the control group, experimental group 3 decreased more significantly (P<0.01, P<0.05).3. Two points efficacy of TCM comparison:trial basic recovery group after treatment in 12 cases, effective in 10 cases, effective in 6 cases and 3 cases, the total effective rate 90.32; control group, basic recovery group after treatment in 2 cases, effective in 3 cases, effective in 4 cases, ineffective in 22 cases, the total effective rate 29.03. TCM efficacy of the test group significantly better than the control group, the two groups by the Mann-Whitney U test P<0.01, difference was highly significant.[Conclusion]Through clinical observation, modified Danzhi Xiaoyaosan can be significantly improved in patients with diabetes and depression depression and insomnia, fatigue and other symptoms and increase their compliance with treatment, reduce negative emotions lead to insulin resistance, beneficial blood sugar control and improve the quality of life of patients, Therefore, the clinical deserves to be widely promoted. |
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