TCM Cause And Pathogenesis Of 100 Cases Of Ulcerative Colitis On Clinical Research

Objective:Ulcerative colitis (ulcerative colitis, UC) is a mainly involving the rectum and colon mucosa of chronic non-specific inflammation, referred to as ulcerative colitis, an inflammatory bowel diseases (IBD) category. Clinically, abdominal pain, diarrhea, mucus blood and pus, tenesmus as the main performance. The disease cases concentrated in the northern hemisphere, especially the United States, Canada, Northern Europe, Scandinavia and Israel, our people's living standards in recent years and the living environment changes, the incidence of this disease have increased, has become of common ailments. In addition, the disease has been included in 1950, "psychosomatic illness" category. The disease can be attributed to the medicine, "intestinal secluded", "dysentery," "diarrhea" and "pain" and other areas, especially with the TCM "rest scour" the closest. In clinical treatment, Chinese medicine is often able to obtain satisfactory results, in the maintenance of remission and relapse in reducing the role of Chinese medicine than western medicine has been recognized as an advantage, and the toxic side effects, the economic burden of light, therefore, we collect clinical data of UC to explore its cause and pathogenesis, and to further explore prevention and treatment of this disease in Chinese medicine principles, in order to provide a reference for the basis for prevention and treatment of UC.Methods:This issue under the guidance of TCM theory, a questionnaire survey to collect clinical data of UC patients (mainly patients with general information, medical history, clinical symptoms, signs, laboratory tests, etc.) to carry out clinical and epidemiological survey questionnaire with "973" program issues-symptoms of norms and system of the dialectical method-Elements of Hou evidence-cross-sectional survey of clinical epidemiology-Ulcerative Colitis Information Form, and research purposes under the appropriate changes. All 100 patients from August 2008-2,009 in March at a hospital in Wuhan City Department of Gastroenterology and Huazhong University of Science Medicine, Union Hospital, Tongji Medical College, Division of patients. Data to collate the information collected and entered into the computer, through SPSS 17.0 packages on the main symptoms and related data analysis, and then the results of the TCM cluster analysis to explore the cause and pathogenesis of UC machine.Results:1. This sickness active stage common pathogenesis includes:The large intestine hot and damp (presents 58 examples), liver strongly fragrant spleen weakness (to present 36 examples), the taste lacking in vital energy (to present 24 examples), the spleen kidney deficiency of yang (to present 21 examples), the lacking in vital energy (to present 18 examples) the blood stasis intestines to wind (presents 12 examples) and the blood deficiency and related debilities (presents 10 examples) several aspects, large intestine hot and damp Chang Yugan the strongly fragrant spleen weakness concurrently presents (altogether 36 examples), next often concurrently lacking in vital energy (altogether 18 examples); The blood stasis intestines wind Chang Jianyi the blood deficiency and related debilities (altogether 10 examples), taste lacking in vital energy Chang Jianyi spleen kidney deficiency of yang (altogether 21 examples); Presents the frequency looking from the card period of five days, in 94 example UC active stage patient, appears card period of five days (including moreover card, compound card) altogether 7 kind,179 times.2. The sex to this sickness's morbidity non-statistics significance, the average morbidity age men and women group does not have the difference; UC is taken bad in various ages, in peak age set of intervals in 32-42 years old.3. The morbidity cause, individual history (smoking, diet and so on) are by chance influential to the UC morbidity. The movement or tired, factors and so on food, mood fluctuation cause the morbidity the frequency to be highest, because of infects is taken bad or the aggravation are least, only presents 6 examples. And the mood fluctuation influencing factor men and women group has statistics difference.4.UC clinical divides and the course is influential to the Chinese medicine cause of disease pathogenesis, is taken bad the pathogenesis to be pure for the first time, a course longer pathogenesis is more complex, the reality is being calmly more obvious.5. the liver strongly fragrant spleen weakness pathogenesis's occurrence men and women group has statistics difference, the female is easier to have the liver strongly fragrant spleen weakness pathogenesis.6. In 100 example investigation case, only some 4 examples determined that has the family to inherit the history,96 examples had not discovered that has the family to inherit the history.Conclusion: 100 cases through the investigation of patients with ulcerative colitis, the following conclusions:(1) UC activity of disease-bit accumulate mainly colorectal, liver, spleen, stomach and kidney, to the vacuity for the disease characteristics of the machine, spleen deficiency and heat Implication intestine throughout to form a protraction of the disease, easily recurrence. Pathological changes in patients in remission is mainly empty, mainly heart and spleen qi deficiency, lack of precision of blood throughout the course of disease remission, spleen deficiency is the ease of transition to the activities of the key. (2) sex on the incidence of this disease was not significant, men and women suffering from this disease very likely. (3) The disease mainly in young people. (4) exerting internal injuries, emotional disorders and eating Disloyalty UC onset or worsening leading to the main factors. (5) probability of stagnation and spleen deficiency occur in women than on men. (6) in UC pathogenesis in the distribution of clinical types have different pathogenesis of early onset patients with standard solid-based, and mainly to Damp intestine, while unusual resistance network congestion; chronic relapsing disease in patients with the most complex machine, This shows the typical vacuity; also shows that the complexity of this disease is increasing with the prolonged course of the disease, and that the longer the duration, the more obvious spleen deficiency. (7) There is no clear evidence that infections and genetic factors is directly induced UC.