Relationship Between Liver-kidney Yin Deficiency And Vascular Endothelial Dysfunction

Objective:To investigate the relationship between liver-kidney yin deficiency and vascular endothelial dysfunction.Method:Selecting 60 cases of liver-kidney yin deficiency and 60 cases of non liver-kidney yin deficiency according to Syndrome Differentiation of TCM, and selecting 30 cases of the normal group. The concentration of plasma ET, NO, hs-CRP, vWF and SOD was tested respectively, the relationship between the above indexes and liver-kidney yin deficiency was analyzed.Results:Compared with the normal group, the concentration of plasma ET, vWF and hs-CRP were significantly increased (p<0.01) in the groups of liver-kidney yin deficiency and non liver-kidney yin deficiency. Compared with the normal group, the concentration of plasma NO and SOD were significantly decreased (p<0.01) in the groups of liver-kidney yin deficiency and non liver-kidney yin deficiency. Compared with non liver-kidney yin deficiency group, the concentration of plasma ET and vWF were significantly increased (p<0.01), the concentration of plasma SOD were significantly decreased (p<0.05), the concentration of plasma NO were significantly decreased (p<0.01) in the group of liver-kidney yin deficiency. The TCM dyndrome evaluation of liver-kidney yin deficiency and the concentration of plasma ET had positive correlation (r=0.890, p<0.01), the TCM dyndrome evaluation of liver-kidney yin deficiency and the concentration of plasma NO had negative correlation (r=-0.885, p<0.01), the TCM dyndrome evaluation of liver-kidney yin deficiency and the concentration of plasma SOD had negative correlation (r=-0.708, p<0.01), the TCM dyndrome evaluation of liver-kidney yin deficiency and the concentration of plasma vWF had positive correlation (r=0.839, p<0.01), the TCM dyndrome evaluation of liver-kidney yin deficiency and the concentration of plasma hs-CRP had no obvious correlation (r=0.282, p>0.05).The TCM dyndrome evaluation of non liver-kidney yin deficiency and the concentration of plasma ET, NO, hs-CRP, vWF and SOD had no obvious correlation.Conclusion:The vascular endothelial dysfunction was possibly the pathophysiologic basis of liver-kidney yin deficiency.