Epidemiological Survey Of Prevalence Of Nonalcoholic Fatty Liver Disease And Its Risk Factors In Civil Servant Of Urumqi

Objective:To investigate the prevalence, correlated biochemical indexes and major risk factors of nonalcoholic fatty liver disease (NAFLD) among civil servant examination receivers in Urumqi. Methods:2074 participants were investigated in the First Affiliated Hospital, the Forth Affiliated Hospital of Xinjiang Medical University during January. 2008 to August.2009. Questionnaire, physical examination, serum biochemical examination and ultrasonographic examination of liver were under taken. Results:A total o f 2 074 receiver took part in the survey. Among the 2 074 participants,1 138 were males and 936 were females. Among which 33.94% had nonalcoholic fatty liver. It was 49.65% in males and 15.17% in females. The prevalence of NAFLD in males was significantly higher than that in females (P<0.01). The prevalence of NAFLD in Uygur nationality was 40.78% and it was 33.37% in Han nationality.There is no significant difference on the prevalence of NAFLD between the Uygur nationality and the Han nationality in groups younger than 50 years old (P>0.05), but in the 50-aging group, the prevalence of NAFLD in the Uygur nationality is higher than that in the Han nationality (P<0.05). The body mass index (BMI), blood pressure, fasting serum glucose level (FPC), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), r-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), Serum urea (BUN), creatinine (CRE), Uric acid (UA) in the NAFLD group were significantly higher than those in the group without fatty liver (P<0.05), respectively), but the high-density lipoprotein cholesterol (HDL-C) level was lower in NAFLD group (P <0.01).Logistic regression analysis demonstrated that the prevalence of NAFLD was positively correlated to seven factors, including male sex, obesity, heavy drinking, diabetes mellitus, hypertension, dyslipidemia and HDL-C (P<0.01 respectively) The risk of NAFLD determined by multivariate logistic regression analysis were enumerated in order of OR value as fellow:drinking, obesity, dyslipidemia, diabetes mellitus, hypertension, age, lower HDL-C, post, male (P<0.01 respectively).The influence of nationality, literacy, smoking were smaller. Conclusions:There is a high prevalence of NAFLD among civil servant examination receivers in Urumqi. Metabolic disorders such as obesity and diabetes mellitus, hypertension and hyperlipidemia are closely associated with NAFLD in Urumqi. The serum GGT level can be treated as a predict index of NAFLD.