The Epidemiological Survey Of Prevalence And Characteristics Analysis Of Nonalcoholic Fatty Liver Disease Among2453Health Examination Cases Of Jinan City

ObjectiveTo investigate the prevalence and risk factors of Non-alcoholic fatty liver disease (NAFLD) among health examination cases in the medical examination center of Jinan Central Hospital Affiliated To Shandong University.MethodA total of2453cases with complete information in our physical examination center from November2012to February2013were included in this study.1.The prevalence of NAFLD was determined in different sexual and age groups.2. Detected all the patients general clinical data, including gender, age, systolic blood pressure(SBP) and diastolic blood pressure(DBP).3.Use case-control study, patients were divided into two groups(NAFLD and non-NAFLD) and compared their characteristics, biochemical and metabolic components, such as blood pressure(BP), liver function(Alt, Ast, GGT), fasting blood glucose (FBG), blood lipids(TG, TCH, LDL-C, HDL-C) and uric acid(UA).SPSS13.0was used to do the statistical analysis. Data was expressed bymean number±standard deviation (x±s), non-normal data can be analyzed after logarithmic conversion. Variance analysis and t test were applied in the comparison among many groups. Simple correlation and Multiple regression analysis was used in our study. P<0.05means that there was statistically significant.Results1. Fatty liver was detected in2453cases with abdominal ultrasound test,1498cases were diagnosed NAFLD. The overall prevalence rate was26.2%; the prevalence rate difference between men and women was statistically significant (P<0.05). After gender and age stratification, the prevalence peak age distribution for the male and the overall were60～90and40～49years old group; For female, it was60～90years old group.There was no statistically significant difference between female prevalence rate and that of Male more than60years old(P<0.05).2. Univariate factor analysis:The NAFLD group’s SBP, DBP, ALT, AST, GGT, FBG, TG, TCH, LDL-C, HDL-C, UA on average were higher than those in control group, comparison between the two groups were significantly different (p<0.001). The results shows that gender (OR=5.011, OR95%CI:4.171～6.022), hypertension (OR=4.668, OR95%CI:3.669～5.940), coronary heart disease (OR=4.082, OR95%CI:2.277-7.320), ALT elevations (OR=6.357, OR95%CI:4.595～8.794), AST elevations (OR=4.245, OR95%CI:2.412～7.471), GGT elevations (OR=9.291, OR95%CI:6.917～12.479), FBG elevations (OR=5.904, OR95%CI:4.223～8.255), hypertriglyceridemia (OR=8.522, OR95%CI:6.718～10.809), hypercholesterolemia (OR=2.376, OR95%CI:1.663～3.393), hyper low density lipoproteinemia (OR=3.384, OR95%CI:2.829～4.049), Low levels of HDL-C (OR=4.055, OR95%CI: 2.952-5.570), hyperuricemia (OR=5.851, OR95%CI:4.107-8.335) between NAFLD and control group were statistically significant (P<0.001); gallbladder polyps (OR=1.718, OR95%CI:1.237～2.387) was also statistically significant (P<0.05); cholecystolithiasis (OR=1.552, OR95%CI:0.846-2.849) wasn’t statistically significant (P>0.05)3. The multivariate Logistic regression analysis:The relationships of the factors weer synthetical analyzed in the study,using the multivariate Logistic regression analysis.The results demonstrated that gender (OR=2.522, OR95%CI:2.018～3.151), hypertension (OR=1.750, OR95%CI:1.296～2.363)、coronary heart disease (OR=1.512, OR95%CI:0.754～3.034)、gallbladder polyps (OR=1.720, OR95%CI:1.154～2.565)、age (OR=1.381, OR95%CI:1.257～1.517), ALT elevations (OR=3.582, OR95%CI:2.270～5.654), GGT elevations (OR=2.297, OR95%CI:1.592-3.315), FBG elevations (OR=2.785, OR95%CI:1.856～4.178), hypertriglyceridemia (OR=3.369, OR95%CI:2.530～4.487)、hyper low density lipoproteinemia (OR=2.032, OR95%CI:1.620-2.548)、Low levels of HDL-C (OR=2.597, OR95%CI:1.742～3.874)、hyperuricemia (OR=2.132, OR95%CI:1.378～3.298) were positively correlated with the occurrence of NAFLD, their respective value of OR was larger than1, as independent risk factors for NAFLD.Conclusion1.There were obvious differences in prevalence of NAFLD disease among different age groups both in males and females in population of Jinan City; the prevalence rate of overall was31.02%, and there are significant differences between men and women before the age of60.2. Hypertension, elevated fasting blood glucose, hypertriglyceridemia, hyper low density lipoproteinemia, Low levels of HDL-C and hyperuricemia maybe independent risk factors for NAFLD.3.NAFLD showed liver function damage, mainly to ALT, GGT, and easily combine with hypertension, coronary heart disease, insulin resistance, hyperuricemia, abnormal lipid metabolism and gallbladder polyps.