Study On Correlation Between Homocysteine And The Risk Of Coronary Heart Disease In Postmenopausal Female Population

Objective:statistical compared the homocysteine levels between groups respectively, explore the correlation between the plasma homocysteine levels and the risk of coronary heart disease in postmenopausal female population, in order to facilitate the prevention and treatment on female patients with coronary heart disease. Method:Collect elbow venous blood of all 244 volunteers (aged 45～75years) before coronary angiography, test their plasma homocysteine levels by ELISA. Randomly sampled in total all cases of volunteers screened by coronary angiography,59 cases of postmenopausal female CHD patients as observation group,63 cases of male CHD patients and 60 cases of nonmenopausal healthy female,62 cases of postmenopausal healthy female as control group, analyze the correlation between homocysteine levels and gender, age, menopause or not, the degree and range of criminal coronary artery pathologic change, respectively. Result:1) statistically compared the plasma homocysteine levels between groups using a q-test, group of postmenopausal female vs group of male cases with CHD, there is no statistical significance (p>0.05); group of postmenopausal female vs group of perimenopausal healthy female, there is a statistical significance (p<0.01); group of postmenopausal female vs group of postmenopausal healthy female, there is a statistical significance (p<0.05); 2) statistical compared the positive rate of HHcy between four groups using a X-test, group of postmenopausal female with CHD vs group of male with CHD, there is a statistical significance (p<0.05), group of postmenopausal female with CHD vs group of perimenopausal healthy female, there is a statistical significance (p< 0.01); 3)Analyze the correlation between homocysteine levels and age in group of male cases with CHD and group of postmenopausal female using logistic regression analyse, in male group:r=0.020,p=0.877, p>0.05, there is no correlation; in female group:r= 0.306,p=0.000, p<0.01,there is a positive correlation.4) Statistical compared the number of criminal coronary artery and Hcy levels in groups with CHD(male and female) using a q-test, there is no statistical significance respectively, p>0.05. Conclusion:1) Plasma homocysteine level is one of the risks for coronary heart disease; 2)HHcy is a key risk factor for CHD in postmenopausal female population; 3) Homocysteine levels increasing with age in postmenopausal female population, no such performance present in male population; 4)With the number of criminal coronary artery increasing, the plasma homocysteine levels show no responsible ascend whether in group of postmenopausal female with CHD or in group of male with CHD。...