The Postmenopausal Female Estradiol/Testosterone Ratio And Interleukin 6’s Relation With The Degree Of Coronary Artery Stenosis And Vascular Injury

Background Coronary artery heart disease(CHD) is a common disease of the cardiovascular system. Epidemiology shows that CHD mortality accounts for more than half of the total cardiovascular disease mortality, and the incidence of CHD increased year by year with the bad habits of human life, environmental pollution, aging society, the impact of mental stress and other factors. CHD has a significant age dependence, and has a high mortality rate and disability rate. The incidence of coronary heart disease increased significantly in postmenopausal women. studies demonstrated that this is related to metabolic disorder of sex hormones and excessive expression of inflammatory factors. During the development of CHD,IL-6 plays an important role in the inflammatory response and immune response, and is involved in the process of inflammatory injury.Objective To observe the impact of changes in the postmenopausal female serum sex hormones and interleukin 6(IL-6) level, and the stent implantation on the degree of coronary artery stenosis,to further explore that the effects of sex hormone levels in the pathogenesis of CHD.Methods 134 newly diagnosed female patients with coronary heart disease(CHD) and the menopause over 2 years, aged from 55 to 82(69.8±9.6). All patients need to do the selective coronary angiography after admission(CAG), and according to whether or not there exists hemadostenosis, these patients are divided into 2 groups: the CHD group(86 cases), and the control group(48 cases). And based on the Gensini score, the CHD group is further divided into 3 groups: group A(23 cases), group B(36 cases), and group C(25 cases). As to the patients with coronary artery stenosis > 70% and the coronary artery stent implantation, according to whether or not they are going to undergo surgery, the CHD group is divided into 2 groups: the stent group(the group PCI, 50 cases) and the contrast group(the group CAG, 38 cases). All patients have to be detected by blood estradiol(E2), testosterone(T) and interleukin 6(IL-6) before and after they undergo the coronary angiography or the stent implantation, and then analyze the result of different groups.Results(1) Compared with the control group, patients from the CHD group present a significantly decreased E2 and estradiol/testosterone(E2/T) ratio(all P<0.05), and a significantly increased IL-6(P<0.01);(2) With the aggravating degree of coronary artery stenosis, E2/T of group A, group B and group C is gradually reduced(F=5.529,P=0.009); the blood level of IL-6 is also gradually increased(F=11.091,P=0.000);(3)Compared with the CAG group, the levels of blood IL-6 of PCI group is significantly increased(P<0.05);(4)The blood level of IL-6 and E2/T were significantly changed. Compared with preoperative group, after stent implantation 1 day, 3 days and 7 days, patients present a significantly changed E2/T and IL-6(χ2=16.416,P=0.001; χ2=69.381,P=0.000).Conclusion The degree of coronary artery stenosis of the Postmenopausal women is highly related with the height of IL-6 and E2/T; vascular injury may induce the blood level of IL-6 to rise rapidly and E2/T to rise relaxedly; keep the balance of E2/T may help to curb the inflammation activity of the coronary.