| Objective:To observe the effects of XiTongLing Granules Treating on osteoarthritis(OA) of the knee,which present pain,tendness,tumefuction and dysfunction,and estimate curative effect and security of that. And to discuss its mechanism by systematic clinical observation primarily.Methods:Sixty cases of knee OA patients who were determined deficiency of kidney and cold coagulation,stagnation of blood stasis were divided randomly into the control group and the treatment group, the former was treated with Xitongling Granules and analogue II and the latter with Jinggutongxiao pill and analogue I. Four weeks is a course of treament. A comparative study on clinical curative effect between the changing mark of each main and primary symptom or sing in the 2nd,4th and 8th week and the summarized marks of the main and primary symptoms or sings in the 4th week respectively in the two groups.And observedXitongling"s security,judged its clinical effect.Results:The score of each main and primary symptom or sign in the 2nd,4th and 8th week and the summarized marks of the main and primary symptoms or signs in the 4th week comparing with those diagnosing for the first time in two groups were statistic significant (P<0.05).The reduction of the score of the symptom "joint disable"in 4 weeks were statistic significant (P<0.05).The two groups have no obvious difference in comparing the total clinical curative effect after 4 weeks (P<0.05). No side effect is appeared and the patients'breath, heart rate, pulse, blood pressure and the other laboratory examination indexes have not changed during the treatment.Conclusion:Xitongling Granules andJinggutongxiao pill can reduce the Knee OA patients'scores of the main and primary symptoms or signs.But in alleviating the symptom "stiffness or pain after getting out of the bed" in 2 weeks and the symptom "joint disable" in 4 weeks, Xitongling Granules is obviously superior to Jinggutongxiao pill, ameliorate quality of life and its clinical use is safe.
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