Explore The Serum Level Of IL-17,IL-18 In Patients With Chronic Obstructive Pulmonary Disease In Medium Elevation Area

Through the research we find promote inflammatory cytokine IL-17 . It is produce by actived CD+4 lymphocyte,Chemotactic factors produced by lymphocyte ,Which can modulate cytotoxic Tcell, macrophages, neutrophils . Especially neutrophils raise in airway, Cause acute attack of chronic obstructive pulmonary disease. IL-8 promote proliferation of NK Cell and Tcell, The raise of apoptosis ligands of t cell and lymphocyte,Expression of activation ligands. The T cell infiltrate the airway ,around the pulmonary vascular and lung parenchyma of chronic obstructive pulmonary disease. With low-pressure and hypoxia,cold ,dry about plateau , Seriously influence Oxygen metabolism and Lung function of people of plateau, caused physiologically and pathologically damage for internalize,So chronic obstructive pulmonary disease is Common diseases and frequently-occurring disease for the people in the plateau. The report of the pathogenesis about chronic obstructive pulmonary disease is very little.Objective Observe the the serum level of IL-17,IL-18 in chronic obstructive pulmonary disease during the Acute remission and stable phase in Xining area. Explore the meaning of the IL-17,IL-18 serum level change in the chronic obstructive pulmonary disease. Methods Chose 107 patients with COPD who were diagnosed and treated with from August 2009 to August 2010 at QinHai province people's hospital as research group . through the adopt double antibody sandwich enzyme-linked immunosorbent adsorption method (ELISA) test to detect the serum level of IL - 17, IL– 18 respectively in COPD acute period group(n=76), COPD acute exacerbation period group(n=31) and control group.Results The level of IL-17 in Acute period of COPD groups(11.66±2.73) is higher than those in stable phase(4.47±1.31) and the control group(4.048±0.79), there are statistically significant (p < 0.01), The level of IL-18 in Acute period of COPD groups(121.76±29.42) is higher than those in stable phase(75.45±29.42)and the control group(65.13±25.23), was statistically significant (P < 0.01) ; The level of IL-17 in stable phase COPD groups(4.47±1.31) is higher than those inthe control group(4.048±0.79); There have no statistically between the level of IL-18 in the stable phase and control group.COPD acute period and circulating serum IL– 17 IL - 18 level and FEV₁ accounted for expected value %are negatively correlated . (r_IL-17=-0.653;r(_IL-18)=-0.765)There were statistically significant (P < 0.01). Conclusion Our results address that IL-17,IL-18 play a role in the pathogenesis of COPD; there has negative correlation between level of IL-17,IL-18 and value% FEV_1.0 with acute exacerbation period COPD and stable phase; IL-17,IL-18 are part of airway inflammation in AECOPD, so that induce the formation of airflow obstruction. Serum level of IL-17,IL-18 in AECOPD patients correlated with airway inflammation and airflow obstruction; suggest that serum level of IL-17,IL-18 should be one of the diagnosis criteria for COPD.