Observation Of Pattern Visual Evoked Potential In Patients With Migraine

Objective:Visual evoked potential (evoked potentials, pattern visual PVEP) changes were observed in patients with different types of migraine and the difference about ectrophysiology in PVEP and the relationship between PVEP and visual aura in migraine were analyzed, so as to provide objective indicators for differential diagnosis of headache and treatment in headache.Methods:168 patients with migraine were selected in Shandong University Affiliated Provincial Hospital and in the third People's Hospital of Jinan from 2009 April 1 to 2011 February 1st.168 cases were divided into 2 groups according to migraine types, including migraine with visual aura type group and migraine without aura group. All cases accepted visual evoked potential (pattern visual evoked PVEP) test during headache episode. Visual evoked potential differences were analyzed between the two groups.Result:Among the 168 patients with migraine, PVEP was abnormal in 88 patients (52.4%) and normal in 80 patients (47.6%)In MA group, there were the same abnormal manifestations including low amplitude of N75, P100; delay latency of P100; latency delay and low amplitude of N75, P100 and P100. PVEP was normal in 12 cases (37.5%) and abnormal in 20 cases (62.5%). One unilateral low amplitude of N75, P100 in 2cases, bilateral in 2 cases; unilateral latency delay of P100 in 4 cases? bilateral delay in 6 cases; Unilateral low amplitude of N75, P100 and delay latency of P100 in 2cases, bilateral in 4 cases.In MO group, PVEP was normal in 68 cases (50.0%), abnormal in 68 cases (50.0%), unilateral low amplitude N75,P100 in 14 cases, bilateral in 8 cases; unilateral delay latency of P100 in 6 cases of, bilateral in 6 cases; Unilateral low amplitude of N75, P100 and delay latency of P100 in 16 cases, bilateral in 18 cases.Conclusions:(1) The abnormal rate of PVEP is higher in migraine patients than in healthy controls; (2) The abnormal rate of PVEP is higher in patients with MA than those with MO. The data suggest that the visual aura in migraine is correlated with abnormal PVEP and the latter could be used as objective index in the differencial diagnosis in patients with headache.