Aretrospective Analysis Of 62 Patients With Psoriasis

Objective: To investigate the characters of epidemiology and clinical manifestations of psoriasis in Shantou area. Finally, provide reasonable methods for prevention and treatment.Method: 62 patients with psoriasis during January 2003 to December 2010 in the Department of Dermatology, the First Affiliated Hospital, ShanTou University Medical College were retrospectively analyzed. We analyzed the general data, age of onset, subtypes of psoriasis, previous medication, family history, concomitance diseases, provocation factors and distribution of skin lesion. Theχ2-test and Student's t-test were used for statistical comparison.Results: (1) There were 35 males and 27 females in the group, which had no significant difference in the gender distribution. The average age of the first onset was 36.3 years old; the average age of the first onset of males and female patients was 38.6 years old and 33.3 years old, respectively. (2) The onset, aggravation and recurrence of psoriasis mostly happened in winter and spring, and released in summer and autumn. (3) Infections and abused herbs were the prominent factors for trigger or aggravation of psoriasis. (4) The most common subtype of psoriasis was psoriasis vulgaris (90.32%), followed by generalized pustular psoriasis (4.84%) and psoriasis arthropathica (4.84%) in the group. The subtypes of recurrence psoriasis were psoriasis vulgaris (38.71%), generalized pustular psoriasis (38.71%), psoriatic erythroderma (16.13%) and psoriasis arthropathica (6.45%). (5) Most of the initial rash appeared on the scalp and trunk. (6) Most of the patients were treated with antihistaminics, corticosteroids, retinoids and Chinese herbs by oral taking and topical corticosteroids, vitamin D3 products and Chinese herbs were used external before attending to the hospital. (7) These patients had a higher incident to accompany with other diseases (74.19%), 3.22% of which accompany with viral hepatitis, 3.22% with pulmonary infection, 2.22% with urinary infection, 3.22% with herpesvirus infection, 6.45% with diabetes, 6.45% with hyperuricemia, 11.29% with hyperlipidemia, 48.39% with hypoproteinemia, 11.74% with hypertension, 8.06% with coronary heart disease, 8.06% with various types of arrhythmia, 6.45% with fatty liver. (8) 37.10% of these psoriatic patients had leukocyte increase, 14.52% of had hemoglobin decrease, 22.58% had platelet increase, 9.68% had positive urine leukocyte, 6.45% had positive urinary protein, 4.84% had positive urinary occult blood, 12.90% of these psoriatic patients had ALT increase, 27.42% had AST increase.Conclusions: (1) There was no gender difference in the development of psoriasis. (2) Seasonal factors have an important influence on the aggravation and occurrence of psoriasis. (3) The disease can be trigger or aggravate by infections, so the effective anti-infective treatment was needed. (4) The initial psoriatic lesions were major located on the trunk and scalp. (5) Psoriasis patients had a tendency to accompany with cardiovascular diseases, metabolism syndrome, liver changing and so on, which suggested that psoriasis may be a systemic disease.(6) The treatment of psoriasis should be regular and avoid using the irritative medicine or herbs.