The Polymorphism Of Sites 373 And 1688 Of PECAM-1 Gene In Mucocutaneous Lymph Node Syndrome In Children

Objective To investigate the association between the platelet endothelial cell adhesion molecμLe-1 (PECAM-1) gene locus 373 and 1688 polymorphisms and the risk of children with Mucocutaneous lymph node syndrome (MCLS) and that complicated with coronary artery lesion(CAL).Methods 44 patients with MCLS and 59 healthy controls were genotyped by using polymerase chain reaction-restriction fragment length polymorphism for the loci 373 and 1688 of PECAM-1 gene.Results (1) For locus 373 of PECAM-1 gene polymorphism, there was significant differences between MCLS patients and the controls in genotype frequencies of CC, GG and CG(χ2=8.49, p<0.05); but the allele frequency of C and G between MCLS patients and the control were no significant different (χ2=1.11, p>0.05); there were no significant differences between MCLS patients with CAL and that without CAL in genotype and allele frequencies (χ2=5.19,0.84, both p>0.05). (2) For locus 1688 polymorphism of PECAM-1 gene, there were no significant differences between KD patients and the controls in genotype frequencies of AA, GG and AG and allele frequencies of A and G(χ2=0.24,0.04, both p>0.05); also there were no significant differences between KD patients with CAL and that without CAL in genotype and allele frequencies (χ2=0.376,0.0004, both p>0.05)Conclusion (1) There were significant differences between MCLS patients and the controls in genotype frequencies in locus 373 of PECAM-1 gene; but there might be no significant association between patients with and without complication of CAL. (2) No significant associations might be found in locus 1688 of PECAM-1 gene polymorphism and the risk of MCLS between patients and healthy children or between the patients with or without complication of CAL in this study.