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The patients in Fuke Qianjin oblatum group were treated by Fuke Qianjin oblatum. There were 2 months for a course of treatment. The clinical symptoms, physical signs,examination index (ultrasonic inspection),laboratory data (blood rheology,prealbumin) and indicators of safety (blood routine, liver and renal functions test) before and after treatment were noted and compared.2. 62 SD female rats of SPF grade were randomly divided into High-dose Manpen Zhuyu decoction group, Medium-dose Manpen Zhuyu decoction group, Low-dose Manpen Zhuyu decoction group, Fuke Qianjin oblatum group, Model group and Sham operation group (model group and Sham operation group contain 11 rats, other groups contain 10 rats). Sham operation group was just opened their abdomens without injecting mixed bacteria, other groups'rats were injected mixed bacteria (bacillus coli, beta-hemolytic streptococci, staphylococcus aureus)into two sides of the uterus to induce chronic pelvic inflammatory disease models. At the 12th days, in the model group and sham operation group, the rats were randomly selected to definite that the model with chronic pelvic inflammatory disease is succeeded. At the 14th days, the corresponding drugs were administrated, after 14 days the heart of rats were prick and the blood was obtained to detect blood rheology and determine prealbumin by ELISA method. To observe the uterus by naked eyes and check microscopic the pathological histology of uterus.Results1.Clinical research1.1 The total effective rate was 96.88% in Manpen Zhuyu decoction group, 86.67% in Fuke Qianjin oblatum group, The total effective rate of TCM symptom-complex 100.00% in Manpen Zhuyu decoction group,90.00% in Fuke Qianjin oblatum group, The total effective rate of principal physical sign was 93.75% in Manpen Zhuyu decoction group,83.33% in Fuke Qianjin oblatum group, between two groups there were all significant differences statistically (P<0.05)1.2 The TCM symptom-complex and principal physical sign were improved after Manpen Zhuyu decoction treatment, there were significant differences statistically (P<0.01)1.3 After treatment, the two groups patients with chronic pelvic inflammatory disease'indexes of blood rheology were significantly decreased (P <0.05). Manpen Zhuyu decoction group decreased significantly more in high shear viscosity,medium shear viscosity,plasma viscosity and hematocrit (P<0.05)1.4 After treatment, the prealbumin of two groups patients with chronic pelvic inflammatory disease did not change significantly, there were not significant differences statistically (P>0.05)1.5 The indicators of safety of patients in Manpen Zhuyu decoction group, included blood routine, liver and kidney function (ALT, AST, and Cr, BUN)had no significant differences (P>0.05).2. Basic research2.1 Compare with the Sham operation group in high shear viscosity,medium shear viscosity,low shear viscosity of whole blood, plasma viscosity and hematocrit, the model group was increased significantly, and there were significant differences statistically (P<0.01). Imposed by different factors to each group, In addition to Low-dose Manpen Zhuyu decoction group, High-dose Manpen Zhuyu decoction group. Medium-dose Manpen Zhuyu decoction group have improved the indexes of blood rheology significantly(P<0.05), and there is negative correlation significantly between dose of Chinese materia medica and blood rheology(high shear viscosity,low shear viscosity of whole blood, plasma viscosity).Compare with Fuke Qianjin oblatum group in plasma viscosity, High-dose Manpen Zhuyu decoction group is improved significantly (P<0.01)2.2 Compared with the Sham operation group in intrauterine adhesions or expansion of the uterus,parietal structural lesions,epithelial degeneration and necrosis,chronic inflammatory cell infiltration,intimal edema, epithelial cell proliferation, the damage of model group is severe significantly(P<0.05). In addition to Low-dose Manpen Zhuyu decoction group, High-dose Manpen Zhuyu decoction group. Medium-dose Manpen Zhuyu decoction group and Fuke Qianjin oblatum group improved significantly more (P<0.05), and High-dose Manpen Zhuyu decoction group is better than Fuke Qianjin oblatum group (P<0.05).2.3 The level of prealbumin is not significant difference in the six groups (P>0.05), And there is not significant correlation between dose of Chinese materia medica (P>0.05).Conclusions1. Manpen Zhuyu decoction could reduce the indexes of blood rheology and improve clinical symptoms effectively in patients with chronic pelvic inflammatory disease, and it is safety. But before and after treatment the prealbumin of two groups did not change significantly, there were not ignificant differences statistically (P>0.05)2. Manpen Zhuyu decoction could reduce effectively the model rats'indexes of blood rheology, improve the damage of uterus. The mechanism migth be related to Increasing local microcirculation, strengthening the tissue metabolism, promoting tissue repair and regeneration, to speed up the transformation and absorption of proliferative lesions. But in determination chronic pelvic inflammatory disease the value of the prealbum to be studied further still.
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